Funded in part by Top Sector Agri and Food, GoodMills Innovation GmbH, Dutch Bakery Center
Whole Grain Wheat Consumption Affects Postprandial Inflammatory Response in a Randomized Controlled Trial in Overweight and Obese Adults with Mild Hypercholesterolemia in the Graandioos Study
Hoevenaars FPM, Esser D, Schutte S, Priebe MG, Vonk RJ, van den Brink WJ, van der Kamp JW, Stroeve JHM, Afman LA, Wopereis S
The Journal of nutrition · 34 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Industry funded
- Industry group
- Top Sector Agri and Food
- University or hospital
- Universitair Medisch Centrum Groningen
- University or hospital
- Wageningen University and Research
- Company
- GoodMills Innovation GmbH
- University or hospital
- TNO roadmap Nutrition and Health
- Industry group
- Dutch Bakery Center
- Government
- Topsector Agri & Food
- Grants
- Top Sector Agri and Food (TKI-AF 12083)
Based on 7 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-07-05 · J Nutr · vol. 149 · issue 12 · pp. 2133–2144
- Publisher
- Elsevier BV
- Cited
- 58 citations · more than 93% of similar papers · 3.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 49 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Dietary Effects on Health · Food composition and properties · Nutritional Studies and Diet
- Keywords
- Postprandial, Medicine, Overweight, Internal medicine, Randomized controlled trial, Meal, Endocrinology, Obesity, Gastroenterology, Insulin
- MeSH
- humans, triticum, hypercholesterolemia, obesity, inflammation, double-blind method, postprandial period, adult, aged, middle aged, female, male, overweight
10 authors
From NL
- Femke P. M. HoevenaarsNetherlands Organisation for Applied Scientific Research
- Diederik EsserWageningen University & Research
- Sophie SchutteWageningen University & Research
- Marion G. PriebeUniversity Medical Center Groningen; University of Groningen
- Roel J. VonkUniversity Medical Center Groningen; University of Groningen
- Willem J van den BrinkNetherlands Organisation for Applied Scientific Research
Abstract
Background
Whole grain wheat (WGW) consumption is associated with health benefits in observational studies. However, WGW randomized controlled trial (RCT) studies show mixed effects.
Objectives
The health impact of WGW consumption was investigated by quantification of the body's resilience, which was defined as the "ability to adapt to a standardized challenge."
Methods
A double-blind RCT was performed with overweight and obese (BMI: 25-35 kg/m2) men (n = 19) and postmenopausal women (n = 31) aged 45-70 y, with mildly elevated plasma total cholesterol (>5 mmol/L), who were randomly assigned to either 12-wk WGW (98 g/d) or refined wheat (RW). Before and after the intervention a standardized mixed-meal challenge was performed. Plasma samples were taken after overnight fasting and postprandially (30, 60, 120, and 240 min). Thirty-one biomarkers were quantified focusing on metabolism, liver, cardiovascular health, and inflammation. Linear mixed-models evaluated fasting compared with postprandial intervention effects. Health space models were used to evaluate intervention effects as composite markers representing resilience of inflammation, liver, and metabolism.
Results
Postprandial biomarker changes related to liver showed decreased alanine aminotransferase by WGW (P = 0.03) and increased β-hydroxybutyrate (P = 0.001) response in RW. Postprandial changes related to inflammation showed increased C-reactive protein (P = 0.001), IL-6 (P = 0.02), IL-8 (P = 0.007), and decreased IL-1B (P = 0.0002) in RW and decreased C-reactive protein (P < 0.0001), serum amyloid A (P < 0.0001), IL-8 (P = 0.02), and IL-10 (P < 0.0001) in WGW. Health space visualization demonstrated diminished inflammatory (P < 0.01) and liver resilience (P < 0.01) by RW, whereas liver resilience was rejuvenated by WGW (P < 0.05).
Conclusions
Twelve-week 98 g/d WGW consumption can promote liver and inflammatory resilience in overweight and obese subjects with mildly elevated plasma cholesterol. The health space approach appeared appropriate to evaluate intervention effects as composite markers. This trial was registered at www.clinicaltrials.gov as NCT02385149.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.