Processed Meat Intake and Bladder Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cohort
Xu X
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 16 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Grants
- National Natural Science Foundation of China (81702500)
Based on 1 listed funder(s).
Publication
- Published
- 2019-09-18 · Cancer Epidemiol Biomarkers Prev · vol. 28 · issue 12 · pp. 1993–1997
- Publisher
- American Association for Cancer Research
- Cited
- 20 citations · more than 91% of similar papers · 3.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 23 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Agriculture Sustainability and Environmental Impact · Edible Oils Quality and Analysis
- Keywords
- Medicine, Bladder cancer, Prostate cancer, Red meat, Internal medicine, Colorectal cancer, Prospective cohort study, Cancer, Cohort study, Incidence (geometry), Lung cancer, Cohort, Prostate, Confidence interval, Processed meat, Oncology, Gynecology, Pathology, Biology, Food science
- MeSH
- humans, prognosis, incidence, risk factors, follow-up studies, prospective studies, meat, middle aged, united states, female, male, urinary bladder neoplasms, early detection of cancer
1 author
From CN
- Xin Xu · correspondingZhejiang University
Abstract
Background
The association between processed meat intake and bladder cancer risk has been evaluated by several observational studies with inconsistent results.
Methods
In a cohort of 101,721 subjects in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, we analyzed the association of processed meat intake with bladder cancer risk.
Results
After a median of 12.5 years of follow-up, 776 new cases of bladder cancer were identified. Intake of processed red meat was significantly associated with the incidence of bladder cancer after multivariate adjustment [highest vs. lowest quintile: HR, 1.47; 95% confidence interval (CI), 1.12-1.93; P trend = 0.008]. In contrast, there was only a suggestive but not significant association between intake of total processed meat and bladder cancer risk after multivariable adjustment (highest vs. lowest quintile: HR, 1.16; 95% CI, 0.89-1.50; P trend = 0.073).
Conclusions
This large prospective study suggests that intake of processed red meat is associated with a higher risk of bladder cancer.
Impact
Bladder cancer risk is increased with cumulative intake of processed red meat.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.