Cold exposure induces dynamic, heterogeneous alterations in human brown adipose tissue lipid content
Coolbaugh CL, Damon BM, Bush EC, Welch EB, Towse TF
Scientific reports · 32 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- University or hospital
- Vanderbilt University
- Government
- National Institutes of Health
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Institute of Biomedical Imaging and Bioengineering
- Government
- National Center for Advancing Translational Sciences
- Government
- NIDDK NIH HHS
- Government
- NIBIB NIH HHS
- Government
- NIH HHS
- Government
- NCATS NIH HHS
- Grants
- National Center for Advancing Translational Sciences (TR-000445); National Institute of Diabetes and Digestive and Kidney Diseases (UL1 TR000445); National Center for Advancing Translational Sciences (UL1TR000445)); National Institute of Biomedical Imaging and Bioengineering (T32 EB001628); National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK-105371); National Institutes of Health (1s10od021771-01); Vanderbilt University (TR000445); National Institutes of Health (NIH-R01); National Institutes of Health (R01DK); National Institute of Diabetes and Digestive and Kidney Diseases (NIH R01); National Center for Advancing Translational Sciences (NIH UL1); National Institutes of Health (TR000445); National Institutes of Health (UL1-TR-000445)
Based on 9 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-09-19 · Sci Rep · vol. 9 · issue 1 · p. 13600
- Publisher
- Nature Portfolio
- Cited
- 38 citations · more than 90% of similar papers · 2.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 74 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Adipose Tissue and Metabolism · Cardiovascular Disease and Adiposity · Exercise and Physiological Responses
- Keywords
- Adipose tissue, Brown adipose tissue, Voxel, Lipid metabolism, Chemistry, Lipid oxidation, Lipid droplet, Internal medicine, Magnetic resonance imaging, Endocrinology, Biology, Medicine, Biochemistry, Antioxidant, Radiology
- MeSH
- humans, fatty acids, magnetic resonance imaging, oxidation-reduction, image processing, computer-assisted, adult, adipose tissue, brown, cold temperature, young adult
5 authors
From US
- Crystal L. CoolbaughVanderbilt University Medical Center
- Bruce M. Damon · correspondingVanderbilt University; Vanderbilt University Medical Center
- Emily BushVanderbilt University Medical Center
- Edward Brian WelchVanderbilt University; Vanderbilt University Medical Center
- Theodore F. TowseGrand Valley State University; Vanderbilt University Medical Center
Abstract
Brown adipose tissue undergoes a dynamic, heterogeneous response to cold exposure that can include the simultaneous synthesis, uptake, and oxidation of fatty acids. The purpose of this work was to quantify these changes in brown adipose tissue lipid content (fat-signal fraction (FSF)) using fat-water magnetic resonance imaging during individualized cooling to 3 °C above a participant's shiver threshold. Eight healthy men completed familiarization, perception-based cooling, and MRI-cooling visits. FSF maps of the supraclavicular region were acquired in thermoneutrality and during cooling (59.5 ± 6.5 min). Brown adipose tissue regions of interest were defined, and voxels were grouped into FSF decades (0-10%, 10-20%…90-100%) according to their initial value. Brown adipose tissue contained a heterogeneous morphology of lipid content. Voxels with initial FSF values of 60-100% (P < 0.05) exhibited a significant decrease in FSF while a simultaneous increase in FSF occurred in voxels with initial FSF values of 0-30% (P < 0.05). These data suggest that in healthy young men, cold exposure elicits a dynamic and heterogeneous response in brown adipose tissue, with areas initially rich with lipid undergoing net lipid loss and areas of low initial lipid undergoing a net lipid accumulation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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