Steroidal constituents isolated from the seeds of Withania somnifera
Iguchi T, Kuroda M, Ishihara M, Sakagami H, Mimaki Y
Natural product research · 6 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-09-20 · Nat Prod Res · vol. 35 · issue 13 · pp. 2205–2210
- Publisher
- Taylor & Francis
- Cited
- 7 citations · more than 72% of similar papers · 0.6× the field average
- References
- 10 works
- Access
- Open access (repository copy) · CC-BY
- Research areas
- Phytochemicals and Medicinal Plants · Medicinal Plants and Neuroprotection · Pharmacological Effects of Medicinal Plants
- Keywords
- Withania somnifera, Glycoside, Cytotoxic T cell, Cytotoxicity, Chemistry, Traditional medicine, In vitro, Hydrolysis, Carcinoma Cell, Biochemistry, Stereochemistry, Medicine, Pathology
- MeSH
- cell line, tumor, humans, withania, seeds, steroids, antineoplastic agents, magnetic resonance spectroscopy, cell death
5 authors
From JP
- Tomoki Iguchi · correspondingTokyo University of Pharmacy and Life Sciences
- Minpei KurodaTokyo University of Pharmacy and Life Sciences
- Mai IshiharaTokyo University of Pharmacy and Life Sciences
- Hiroshi SakagamiMeikai University
- Yoshihiro MimakiTokyo University of Pharmacy and Life Sciences
Abstract
A new withanolide glycoside (1), two new ergostanol glycosides (2 and 3), and a new furostanol glycoside (4), along with nine known steroidal derivatives (5-12) were isolated from the seeds of Withania somnifera. The structures of the new compounds were determined using spectroscopic analysis and hydrolysis. The cytotoxic activities of the isolated compounds were evaluated against Ca9-22 human gingival carcinoma cells, HSC-2 human mouth carcinoma cells, and HL-60 human promyelocytic leukemia cells. Only 12 exhibited cytotoxic activity against these cell lines with IC50 values of 0.38, 0.54, and 1.5 μM, respectively.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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