Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial
Zhao J, Giri A, Zhu X, Shrubsole MJ, Jiang Y, Guo X, Ness R, Seidner DL, Giovannucci E, Edwards TL, Dai Q
British journal of cancer · 19 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Health and Human Services
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Government
- NICHD NIH HHS
- Government
- NIDDK NIH HHS
- Government
- NCI NIH HHS
- Government
- U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
- Grants
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12-HD043483); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-058404); U.S. Department of Health and Human Services (U01CA182364); National Institutes of Health (6u01ca182364-03); National Cancer Institute (U01 CA182364)
Based on 9 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-09-22 · Br J Cancer · vol. 121 · issue 9 · pp. 796–804
- Publisher
- Springer Nature
- Cited
- 28 citations · more than 88% of similar papers · 2.3× the field average
- References
- 38 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Colorectal Cancer Screening and Detection · Parathyroid Disorders and Treatments
- Keywords
- Colorectal adenoma, Medicine, Calcium, Colorectal cancer, Adenoma, Internal medicine, Gastroenterology, Endocrinology, Oncology, Cancer
- MeSH
- humans, colorectal neoplasms, ovarian neoplasms, lung neoplasms, prostatic neoplasms, neoplasms, second primary, calcium, magnesium, incidence, aged, middle aged, female, male, early detection of cancer, carcinogenesis
11 authors
From US
- Jing ZhaoVanderbilt University Medical Center
- Ayush GiriVanderbilt University Medical Center
- Xiangzhu ZhuVanderbilt University Medical Center
- Martha J. ShrubsoleVanderbilt University Medical Center
- Yixing JiangUniversity of Maryland, Baltimore
- Xingyi GuoVanderbilt University Medical Center
Abstract
Background
We aimed to evaluate the associations between calcium and various stages of colorectal carcinogenesis and whether these associations are modified by the calcium to magnesium (Ca:Mg) ratio.
Methods
We tested our hypotheses in the prostate lung, colorectal and ovarian cancer screening trial.
Results
Calcium intake did not show a dose-response association with incident adenoma of any size/stage (P-trend = 0.17), but followed an inverse trend when restricted to synchronous/advanced adenoma cases (P-trend = 0.05). This inverse trend was mainly in participants with Ca:Mg ratios between 1.7 and 2.5 (P-trend = 0.05). No significant associations were observed for metachronous adenoma. Calcium intake was inversely associated with CRC (P-trend = 0.03); the association was primarily present for distal CRC (P-trend = 0.01). The inverse association between calcium and distal CRC was further modified by the Ca:Mg ratio (P-interaction trend = 0.04). No associations for calcium were found in the Ca:Mg ratio above 2.5 or below 1.7.
Conclusion
Higher calcium intake may be related to reduced risks of incident advanced and/or synchronous adenoma and incident distal CRC among subjects with Ca:Mg intake ratios between 1.7 and 2.5.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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