The impact of reduced red and processed meat consumption on cardiovascular risk factors; an intervention trial in healthy volunteers
Simpson EJ, Clark M, Razak AA, Salter A
Food & function · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- Medical Research Council
- Government
- Biotechnology and Biological Sciences Research Council
- Government
- Innovate UK
- Grants
- Innovate UK (101732)
Based on 3 listed funder(s).
Publication
- Published
- 2019-01-01 · Food Funct · vol. 10 · issue 10 · pp. 6690–6698
- Publisher
- Royal Society of Chemistry
- Cited
- 16 citations · more than 89% of similar papers · 2.6× the field average
- References
- 28 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Agriculture Sustainability and Environmental Impact
- Keywords
- Red meat, Medicine, Consumption (sociology), Processed meat, Intervention (counseling), Environmental health, Food science, Biology
- MeSH
- animals, chickens, cattle, humans, cardiovascular diseases, risk factors, cohort studies, longitudinal studies, blood pressure, meat products, seafood, adult, middle aged, female, male, cholesterol, ldl, cholesterol, hdl, young adult, healthy volunteers
4 authors
From GB
- Elizabeth J. Simpson · correspondingUniversity of Nottingham; National Institute for Health and Care Research; Queen's Medical Centre; Nottingham Biomedical Research Centre
- Marie A. ClarkUniversity of Nottingham
- Azlina A. RazakUniversity of Nottingham; Queen's Medical Centre
- Andrew M. SalterUniversity of Nottingham
Abstract
Meat represents an important part of the diet for many adults, supplying essential amino acids and micronutrients. However, high red and processed meat (RPM) intake is implicated in the development of cardiovascular disease and dyslipidemia. This study aimed to reduce RPM consumption in healthy, non-obese omnivores (21-48 years), who ate RPM ≥4 times per week, and to investigate its effect on cardiovascular risk factors using a single-group longitudinal study design (comprising an initial 4-week baseline period, followed by a 12-week intervention). Participants (16M : 21F) were assessed before (BL) and after (T0) the pre-intervention period and before (T0), at week 6 (T6) and at the end of intervention (T12). In a subset (8M : 15F), haematological parameters were measured at BL, T6 and T12. Compared with BL, protein intake from RPM reduced by 67% at T6 and 47% at T12 (4-day dietary records). BMI, body fat mass, and blood pressure did not change over the intervention in the whole cohort, but mean total, LDL and HDL cholesterol were reduced in males at T12 (effect sizes -0.52, -0.41 and -0.15 mmol l-1, respectively; each P < 0.01), with no change in total : HDL ratio observed. In the study sub-set, haemoglobin concentration, plus red and white cell count fell during the intervention (estimated effect size ηp2 0.300, 0.301 and 0.354, respectively; each P < 0.001). It was possible for omnivores to approximately halve their RPM intake, and in males this dietary change appeared to reduce blood lipid concentrations. However, acute dietary changes to RPM intake may have had an unfavourable impact on haematological parameters.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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