Red meat consumption, risk of incidence of cardiovascular disease and cardiovascular mortality, and the dose-response effect: Protocol for a systematic review and meta-analysis of longitudinal cohort studies
Medeiros GCBS, Azevedo KPM, Mesquita GXB, Lima SCVC, Silva DFO, Pimenta IDSF, Gonçalves AKDS, Lyra CO, Piuvezam G
Medicine · 18 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- University or hospital
- Universidade Federal do Rio Grande do Norte
- Grants
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior ((Code 001))
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-09-01 · Medicine (Baltimore) · vol. 98 · issue 38 · p. e17271
- Publisher
- Wolters Kluwer
- Cited
- 29 citations · more than 91% of similar papers · 3.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 15 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Meat and Animal Product Quality · Agriculture Sustainability and Environmental Impact
- Keywords
- Medicine, Incidence (geometry), Red meat, Meta-analysis, MEDLINE, Systematic review, Cohort study, Environmental health, Disease, Study heterogeneity, Guideline, Internal medicine, Pathology
- MeSH
- humans, cardiovascular diseases, diet, incidence, risk factors, longitudinal studies, meta-analysis as topic, red meat, systematic reviews as topic
9 authors
From BR
- Gidyenne Christine Bandeira Silva de Medeiros · corresponding
- Kesley Pablo Morais de Azevedo
- Gabriella Xavier Barbalho Mesquita
- Severina Carla Vieira Cunha Lima
- David Franciole Oliveira Silva
- Isac Davidson Santiago Fernandes Pimenta
Abstract
Background
Red and (particularly) processed meats are high in cholesterol and saturated and solid fatty acids. Their consumption is considered one of the risk factors for metabolic disorders. Numerous studies demonstrated a possible association between red meat consumption and cardiovascular disease (CVD). In this protocol, we propose a systematic review of the literature to examine the associations of red meat consumption with CVD incidence and mortality, and explore the potential dose-response relationship.
Methods
We will search MEDLINE/PubMed, Scopus, SciELO, LILACS, ScienceDirect, Web of Science, Cochrane (CENTRAL), WHOLIS, PAHO, and Embase. We will include prospective epidemiological studies (longitudinal cohort). Risk of bias will be assessed using the Newcastle-Ottawa scale (NOS). Four independent researchers will conduct all evaluations. Disagreements will be referred to a fifth reviewer. We will summarize our findings using a narrative approach and tables to describe the characteristics of the included studies. The heterogeneity between trial results will be evaluated using a standard chi-squared test with P < .05. We will conduct the study in accordance with the guideline of the Preferred Reporting Items for Systematic Review and Meta-analyses Protocols (PRISMA-P).
Results
This review will evaluate the association between red meat consumption and incidence of CVD and mortality (primary outcome measures). The secondary outcome measure will include the dose-response effect.
Conclusion
The findings of this systematic review will summarize the latest evidence of the association between red meat consumption and incidence of CVD and mortality and the dose-response effect through a systematic review and meta-analysis.
Registration
PROSPERO CRD42019100914.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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