Dietary Fiber, Whole Grains, and Head and Neck Cancer Prognosis: Findings from a Prospective Cohort Study
Maino Vieytes CA, Mondul AM, Li Z, Zarins KR, Wolf GT, Rozek LS, Arthur AE
Nutrients · 15 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Agriculture
- Government
- National Institutes of Health
- Government
- National Institute of Food and Agriculture
- Government
- National Cancer Institute
- Government
- National Institute for Occupational Safety and Health
- Government
- NCI NIH HHS
- Government
- NIOSH CDC HHS
- Grants
- National Cancer Institute (P50 CA-097248); National Institute for Occupational Safety and Health (T42-OH008455)); U.S. Department of Agriculture (1011487); National Institute of Food and Agriculture (1011487)
Based on 7 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-09-27 · Nutrients · vol. 11 · issue 10 · p. 2304
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 18 citations · more than 85% of similar papers · 1.7× the field average
- References
- 45 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Head and Neck Cancer Studies · Nutrition and Health in Aging · Folate and B Vitamins Research
- Keywords
- Medicine, Head and neck cancer, Hazard ratio, Prospective cohort study, Proportional hazards model, Internal medicine, Whole grains, Cohort, Cohort study, Confidence interval, Cancer, Oncology, Food science
- MeSH
- humans, head and neck neoplasms, neoplasm recurrence, local, prognosis, diet, diet surveys, proportional hazards models, risk factors, prospective studies, dietary fiber, aged, middle aged, female, male, whole grains
7 authors
From US
- Christian A. Maino VieytesUniversity of Illinois Urbana-Champaign
- Alison M. MondulUniversity of Michigan
- Zonggui LiUniversity of Illinois Urbana-Champaign
- Katie R. ZarinsUniversity of Michigan
- Gregory T. WolfUniversity of Michigan
- Laura S. RozekUniversity of Michigan
Abstract
No studies, to date, have examined the relationship between dietary fiber and recurrence or survival after head and neck cancer diagnosis. The aim of this study was to determine whether pretreatment intake of dietary fiber or whole grains predicted recurrence and survival outcomes in newly diagnosed head and neck cancer (HNC) patients. This was a prospective cohort study of 463 participants baring a new head and neck cancer diagnosis who were recruited into the study prior to the initiation of any cancer therapy. Baseline (pre-treatment) dietary and clinical data were measured upon entry into the study cohort. Clinical outcomes were ascertained at annual medical reviews. Cox proportional hazard models were fit to examine the relationships between dietary fiber and whole grain intakes with recurrence and survival. There were 112 recurrence events, 121 deaths, and 77 cancer-related deaths during the study period. Pretreatment dietary fiber intake was inversely associated with risk of all-cause mortality (hazard ratio (HR): 0.37, 95% confidence interval (CI): 0.14-0.95, ptrend = 0.04). No statistically significant associations between whole grains and prognostic outcomes were found. We conclude that higher dietary fiber intake, prior to the initiation of treatment, may prolong survival time, in those with a new HNC diagnosis.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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