Is cholecalciferol a potential disease-modifying anti-rheumatic drug for the management of rheumatoid arthritis?
Bellan M, Andreoli L, Nerviani A, Piantoni S, Avanzi GC, Soddu D, Hayden E, Pirisi M, Sainaghi PP
Clinical and experimental rheumatology · 6 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-03-26 · Clin Exp Rheumatol · vol. 38 · issue 2 · pp. 343–349
- Publisher
- Springer Vienna
- Cited
- 10 citations · more than 70% of similar papers · 0.8× the field average
- References
- 44 works
- Access
- Free to read
- Research areas
- Vitamin D Research Studies · Rheumatoid Arthritis Research and Therapies · Peripheral Neuropathies and Disorders
- Keywords
- Medicine, Rheumatoid arthritis, Vitamin D and neurology, Cholecalciferol, Disease, Drug, Autoimmune disease, Vitamin, Rheumatic disease, Arthritis, Internal medicine, Immunology, Pharmacology
- MeSH
- humans, arthritis, rheumatoid, vitamin d deficiency, cholecalciferol, antirheumatic agents
9 authors
From IT, GB
- Mattia BellanUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”
- Laura AndréoliAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia; University of Brescia
- Alessandra NervianiQueen Mary University of London; William Harvey Research Institute
- Silvia PiantoniAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia; University of Brescia
- Gian Carlo AvanziUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”
- Daniele SodduUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”
Abstract
Vitamin D is a pleiotropic molecule with a well-characterised immunomodulatory activity in vitro; however, its potential clinical application in autoimmune conditions has yet to be clarified. Several authors have investigated the use of vitamin D as a disease-modifying anti-rheumatic drug (DMARD) in rheumatoid arthritis (RA), obtaining divergent conclusions. This systematic review summarises and critically analyses the findings of papers assessing the impact of vitamin D supplementation on pain relief, disease activity, functional status and flare rate. We conclude that the correction of hypovitaminosis D may have a beneficial effect on pain perception; moreover, the achievement of an adequate plasma vitamin D concentration obtained with high-dose regimens might evoke immunomodulatory activities of vitamin D and favourably impact on disease control. Nevertheless, the current evidence is still not strong enough to support the use of cholecalciferol as a DMARD in RA, and further studies are required to clarify this issue.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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