Nutritional factors influencing plasma adiponectin levels: results from a randomised controlled study with whole-grain cereals
Polito R, Costabile G, Nigro E, Giacco R, Vetrani C, Anniballi G, Luongo D, Riccardi G, Daniele A, Annuzzi G
International journal of food sciences and nutrition · 10 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-10-22 · Int J Food Sci Nutr · vol. 71 · issue 4 · pp. 509–515
- Publisher
- Taylor & Francis
- Cited
- 13 citations · more than 81% of similar papers · 1.3× the field average
- References
- 25 works
- Access
- Open access (repository copy) · CC-BY
- Research areas
- Adipokines, Inflammation, and Metabolic Diseases · Food composition and properties · Nutrition and Health in Aging
- Keywords
- Whole grains, Adiponectin, Medicine, Food science, Animal science, Biology, Internal medicine, Obesity, Insulin resistance
- MeSH
- plasma, humans, fatty acids, volatile, diet, fat-restricted, fasting, energy intake, glycemic index, postprandial period, dietary fiber, adult, aged, middle aged, female, male, adiponectin, edible grain, gastrointestinal microbiome, whole grains, metabolic syndrome
10 authors
From IT
- Rita PolitoUniversity of Campania "Luigi Vanvitelli"; CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)
- Giuseppina CostabileFederico II University Hospital
- Ersilia Nigro · correspondingUniversity of Campania "Luigi Vanvitelli"; CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)
- Rosalba GiaccoInstitute of Food Science; National Research Council
- Claudia VetraniFederico II University Hospital
- Gaia AnniballiFederico II University Hospital
Abstract
Data from intervention studies about the effects of a high intake of whole-grain cereals on adiponectin expression are still inconclusive. We evaluated the effects of whole-grain or refined cereals on fasting and postprandial serum adiponectin in people at high cardiovascular risk. According to a randomised controlled parallel group design, participants with metabolic syndrome were assigned to an isoenergetic diet based on either whole-grain cereal (WGC) or refined cereal (RC) products for 12-weeks. Anthropometric and biochemical measures were taken. Compared to baseline, fasting and postprandial serum adiponectin levels increased after both RC and WGC. In the WGC and RC groups combined, adiponectin concentrations significantly increased after 12-week intervention, and are directly associated with plasma SCFAs and acetate. Only increasing whole-grain cereals may not influence adiponectin levels, which could be modified by a fibre rich, low-fat, low-glycemic index diet, possibly through changes in gut microbiota, as suggested by the relation with SCFAs.Clinical Trials number: NCT00945854.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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