Relations of magnesium intake to cognitive impairment and dementia among participants in the Women's Health Initiative Memory Study: a prospective cohort study
Lo K, Liu Q, Madsen T, Rapp S, Chen JC, Neuhouser M, Shadyab A, Pal L, Lin X, Shumaker S, Manson J, Feng YQ, Liu S
BMJ open · 28 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Health and Human Services
- Government
- Women's Health Initiative
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Center for Advancing Translational Sciences
- Government
- NCATS NIH HHS
- Government
- NHLBI NIH HHS
- Government
- NIA NIH HHS
- Grants
- National Center for Advancing Translational Sciences (UL1TR001863Ð); U.S. Department of Health and Human Services (HHSN268201600002 C); National Institutes of Health (HHSN268201600018C); National Heart, Lung, and Blood Institute (HHSN268201600018C); National Institute on Aging (HHSN-271-2011-00004C,); U.S. Department of Health and Human Services (HHSN268201600018 C); National Heart, Lung, and Blood Institute (K23HL140081); National Institute on Aging (HHSN26820044221C); Women's Health Initiative (HHSN268201600018C); Women's Health Initiative (HHSN271201100004C); National Heart, Lung, and Blood Institute (HHSN268201600004C); U.S. Department of Health and Human Services (HHSN268201600003C); National Heart, Lung, and Blood Institute (HHSN271201100004C); Women's Health Initiative (HHSN268201600002C); National Institutes of Health (HHSN268201600003C); U.S. Department of Health and Human Services (HHSN-271-2011-00004C); National Institutes of Health (HHSN268201600004C); National Institutes of Health (HHSN271201100004C); Women's Health Initiative (HHSN268201600003C); National Heart, Lung, and Blood Institute (HHSN26820044221C); U.S. Department of Health and Human Services (HHSN268201600004 C); National Heart, Lung, and Blood Institute (HHSN268201600003C); National Institutes of Health (HHSN268201600002C); Women's Health Initiative (HHSN268201600004C); National Heart, Lung, and Blood Institute (HHSN268201600002C)
Based on 9 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-11-01 · BMJ Open · vol. 9 · issue 11 · p. e030052
- Publisher
- BMJ
- Cited
- 31 citations · more than 82% of similar papers · 1.6× the field average
- References
- 50 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Nutritional Studies and Diet
- Keywords
- Medicine, Dementia, Prospective cohort study, Women's Health Initiative, Cohort, Cohort study, Epidemiology, Gerontology, Cognitive decline, Body mass index, Multivariate analysis, Cognition, Internal medicine, Observational study, Psychiatry, Disease
- MeSH
- humans, dementia, magnesium, diet, cohort studies, prospective studies, memory, postmenopause, dietary supplements, aged, female, surveys and questionnaires, cognitive dysfunction
13 authors
From US, CN
- Kenneth Lo · correspondingBrown University; Guangdong Academy of Medical Sciences; Guangdong Provincial People's Hospital; South China University of Technology
- Qing Liu · correspondingBrown University
- Tracy MadsenBrown University
- Steve RappWake Forest University
- Jiu‐Chiuan ChenUniversity of Southern California
- Marian L. NeuhouserFred Hutch Cancer Center
Abstract
Objective
To examine the associations of dietary and supplemental magnesium (Mg) as assessed by a semi-quantitative food frequency questionnaire with cognitive outcomes among ageing women.
Design
This work conducts a prospective cohort study of participants enrolled in the Women's Health Initiative Memory Study (WHIMS), which was subsequently extended and named WHIMS-Epidemiology of Cognitive Health.
Setting
Forty clinical centres in the USA.
Participants
Postmenopausal women aged 65-79 years without dementia on enrolment.
Main outcome measures
Physician-adjudicated mild cognitive impairment (MCI) and/or probable dementia (PD).
Results
Participants were excluded (n=1006) if they had extreme values of dietary energy intake, had missing or extreme body mass index values, with prevalent MCI/PD at baseline, received only one cognitive assessment or had been followed up for 20 years of follow-up, 765 (11.8%) out of 6473 participants developed MCI/PD. For MCI/PD and MCI, the risks tended to be lower among participants in quintiles Q2-Q5 of Mg consumption compared with those in the lowest quintile. Participants in Q3 had a significantly lower risk of MCI/PD (HR 0.69, 95% CI 0.53 to 0.91) and MCI (HR 0.63, 95% CI 0.45 to 0.87) after multivariate adjustments. No significant association was observed between total Mg intake and PD. The association between total Mg intake, MCI/PD and MCI was non-linear as suggested by the likelihood test.
Conclusions
Total Mg intake between the estimated average requirement and the recommended dietary allowances may associate with a lower risk of MCI/PD and MCI.
Trial registration number
NCT00685009.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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