Role of Prophylactic Magnesium Supplementation in Prevention of Postoperative Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Grafting: a Systematic Review and Meta-Analysis of 20 Randomized Controlled Trials
Chaudhary R, Garg J, Turagam M, Chaudhary R, Gupta R, Nazir T, Bozorgnia B, Albert C, Lakkireddy D
Journal of atrial fibrillation · 20 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-06-01 · J Atr Fibrillation · vol. 12 · issue 1 · p. 2154
- Cited
- 35 citations · more than 65% of similar papers · 0.8× the field average
- References
- 63 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Atrial Fibrillation Management and Outcomes · Parathyroid Disorders and Treatments
- Keywords
- Medicine, Randomized controlled trial, Atrial fibrillation, Placebo, Meta-analysis, Subgroup analysis, Relative risk, Artery, Anesthesia, Internal medicine, Surgery, Cardiology, Confidence interval
9 authors
From US
- Rahul ChaudharyMayo Clinic in Arizona
- Jalaj GargMedical College of Wisconsin; Texas Cardiac Arrhythmia
- Mohit K. TuragamMount Sinai Hospital
- Rohit ChaudharyMayo Clinic in Arizona
- Rahul GuptaWestchester Medical Center; New York Medical College
- Talha F NazirLehigh Valley Hospital-Pocono; Lehigh Valley Health Network
Abstract
Background
Several randomized trials have evaluated the efficacy of prophylactic magnesium (Mg) supplementation in prevention of post-operative atrial fibrillation (POAF) in patients undergoing cardiac artery bypass grafting (CABG). We aimed to determine the role of prophylactic Mg in 3 different settings (intraoperative, postoperative, intraoperative plus postoperative) in prevention of POAF.
Methods
A systemic literature search was performed (until January 19, 2019) using PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials to identify trials evaluating Mg supplementation post CABG. Primary outcome of our study was reduction in POAF post CABG.
Results
We included a total of 2,430 participants (1,196 in the Mg group and 1,234 in the placebo group) enrolled in 20 randomized controlled trials. Pooled analysis demonstrated no reduction in POAF between the two groups (RR 0.90; 95% CI, 0.79-1.03; p=0.13; I2=42.9%). In subgroup analysis, significant reduction in POAF was observed with postoperative Mg supplementation (RR 0.76; 95% CI, 0.58-0.99; p=0.04; I2=17.6%) but not with intraoperative or intraoperative plus postoperative Mg supplementation (RR 0.77; 95% CI, 0.49-1.22; p = 0.27; I2=49% and RR 0.92; 95% CI, 0.68-1.24; p = 0.58; I2=51.8%, respectively).
Conclusions
Magnesium supplementation, especially in the postoperative period, is an effective strategy in reducing POAF following CABG.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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