Processed Meat Intake and Risk of Chronic Obstructive Pulmonary Disease among Middle-aged Women
Varraso R, Dumas O, Boggs KM, Willett WC, Speizer FE, Camargo CA
EClinicalMedicine · 16 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Brigham and Women's Hospital
- Government
- National Institutes of Health
- Government
- Centers for Disease Control and Prevention
- Grants
- Centers for Disease Control and Prevention (R01 OH-10359); National Institutes of Health (UM1 CA 176726)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-08-03 · EClinicalMedicine · vol. 14 · pp. 88–95
- Publisher
- Elsevier BV
- Cited
- 28 citations · more than 86% of similar papers · 1.8× the field average
- References
- 40 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Chronic Obstructive Pulmonary Disease (COPD) Research · Nutritional Studies and Diet · Cardiovascular Health and Risk Factors
- Keywords
- Medicine, COPD, Hazard ratio, Proportional hazards model, Pulmonary disease, Processed meat, Red meat, Internal medicine, Lower risk, Environmental health, Confidence interval, Food science
6 authors
From FR, US
- Raphaëlle Varraso · correspondingInserm; Université de Versailles Saint-Quentin-en-Yvelines; Vieillissement et Maladies Chroniques. Approches Epidémiologiques et de santé publique
- Orianne DumasInserm; Université de Versailles Saint-Quentin-en-Yvelines; Vieillissement et Maladies Chroniques. Approches Epidémiologiques et de santé publique
- Krislyn M. BoggsBrigham and Women's Hospital; Harvard University; Massachusetts General Hospital
- Walter Churchill WillettBrigham and Women's Hospital; Harvard University
- Frank E. SpeizerBrigham and Women's Hospital; Harvard University
- Carlos A. CamargoBrigham and Women's Hospital; Harvard University; Massachusetts General Hospital
Abstract
Background
Processed meat intake may increase the risk of chronic obstructive pulmonary disease (COPD). However, the magnitude of this association may depend on smoking and unhealthy diet. Our aims were to determine whether processed meat intake increased the risk of COPD among middle-aged women, and to estimate the combined impact of high processed meat intake, smoking and unhealthy diet on the risk of COPD.
Methods
Analyses included 87,032 registered nurses from the Nurses' Health Study II (baseline mean age 36.8 years). Over 2,296,894 person-years (1991-2017), we documented 634 incident cases of COPD. Cumulative average of processed meat intake (every 4 years) was divided into never/almost never, < 1 or ≥ 1 servings/week. A score was created to study the impact of 3-risk lifestyle factors.
Findings
In multivariable-adjusted Cox proportional hazards models, after careful adjustment for smoking and unhealthy diet, we observed a positive association between processed meat intake and the risk of COPD: Hazard Ratio (HR, 95%CI) for ≥ 1 servings/week vs. never/almost never = 1.29 (1.00-1.65). In analyses stratified according to smoking or unhealthy diet, processed meat intake was associated with increased risk of COPD only among ever smokers (HR 1.37 [1.01-1.86]), and among women with unhealthy diet (HR 1.39 [1.04-1.85]). The multivariable-adjusted HR for COPD in participants with all 3 high-risk lifestyle factors compared with none was 6.32 (3.67-10.87).
Interpretation
Processed meat intake was associated with elevated risk of developing COPD in middle-aged women, especially in presence of other high-risk lifestyle factors (smoking, unhealthy diet).
Fundings
US CDC and NIH.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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