Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial
Ruggiero C, Baroni M, Bini V, Brozzetti A, Parretti L, Zengarini E, Lapenna M, Antinolfi P, Falorni A, Mecocci P, Boccardi V
Nutrients · 18 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2019-11-15 · Nutrients · vol. 11 · issue 11 · p. 2778
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 23 citations · more than 84% of similar papers · 1.7× the field average
- References
- 40 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Pharmacological Effects and Toxicity Studies
- Keywords
- Cholecalciferol, Calcifediol, Medicine, Vitamin D and neurology, Internal medicine, Parathyroid hormone, Vitamin, Endocrinology, Randomized controlled trial, Polypharmacy, vitamin D deficiency, Calcium
- MeSH
- humans, vitamin d deficiency, cholecalciferol, calcifediol, parathyroid hormone, vitamin d, c-reactive protein, hand strength, treatment outcome, polypharmacy, hospitalization, drug administration schedule, dietary supplements, aged, 80 and over, female, male, biomarkers
11 authors
From IT
- Carmelinda Ruggiero · correspondingUniversity of Perugia
- Marta BaroniUniversity of Perugia
- Vittorio BiniUniversity of Perugia
- Annalisa BrozzettiUniversity of Perugia
- Luca ParrettiUniversity of Perugia
- Elisa ZengariniIstituto Nazionale di Riposo e Cura per Anziani
Abstract
Vitamin D inadequacy is pervasive in the oldest-old. Many vitamin D metabolites are available for supplementation, their effects on the recovery of adequate serum levels remain unknown. We investigate the effects of supplementation with cholecalciferol (D3) and calcifediol (25D3) on serum levels of 25(OH)D, 1-25(OH)D, bone and inflammatory markers, ultimately identifying clinical predictors of successful treatment. Sixty-seven oldest-old individuals were randomized to weekly administration of 150 mcg of 25D3 or D3, from hospital admission to 7 months after discharge. Supplementation of 25D3 and D3 were associated with increasing serum levels of 25(OH)D (p p = 0.01). Participants on 25D3 experienced a steeper rise than those on D3 (group*time interaction p = 0.01), after adjustment for intact parathyroid hormone (iPTH) levels the differences disappeared (intervention*iPTH interaction p = 0.04). Vitamin D supplementation was associated with a decreasing trend of iPTH and C-reactive protein (CRP) (p < 0.001). Polypharmacy and low handgrip strength were predictors of failure of intervention, independent of vitamin D metabolites. In conclusion, D3 and 25D3 supplementation significantly increase vitamin D serum levels in the oldest-old individuals, with a tendency of 25D3 to show a faster recovery of acceptable iPTH levels than D3. Polypharmacy and low muscle strength weaken the recovery of adequate vitamin D serum levels.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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