Funded in part by California Strawberry Commission
The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro
Rutledge GA, Fisher DR, Miller MG, Kelly ME, Bielinski DF, Shukitt-Hale B
Food & function · 29 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Government
- U.S. Department of Agriculture
- Industry group
- California Strawberry Commission
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- NIA NIH HHS
- Grants
- National Institute on Aging (T32-AG-000029); National Institute on Aging (R01 AG029411); National Institute on Aging (P60 AG011268); National Institutes of Health (T32 AG00002941)
Based on 5 listed funder(s).
Publication
- Published
- 2019-01-01 · Food Funct · vol. 10 · issue 12 · pp. 7707–7713
- Publisher
- Royal Society of Chemistry
- Cited
- 46 citations · more than 88% of similar papers · 2.1× the field average
- References
- 31 works
- Access
- Open access (repository copy)
- Research areas
- Phytochemicals and Antioxidant Activities · Natural Antidiabetic Agents Studies · Antioxidant Activity and Oxidative Stress
- Keywords
- Polyphenol, Antioxidant, In vitro, Berry, Chemistry, Anti-inflammatory, Antioxidant capacity, Oxidative stress, Food science, Biology, Biochemistry, Botany, Pharmacology
- MeSH
- microglia, animals, humans, rats, fragaria, fruit, nitric oxide, tumor necrosis factor-alpha, double-blind method, oxidative stress, aging, postprandial period, aged, middle aged, female, male, nitric oxide synthase type ii, blueberry plants
6 authors
From US
- Grant A. RutledgeTufts University; Agricultural Research Service
- Derek R. FisherTufts University; Agricultural Research Service
- Marshall G. MillerTufts University; Agricultural Research Service
- Megan E. KellyTufts University; Agricultural Research Service
- Donna F. BielinskiTufts University; Agricultural Research Service
- Barbara Shukitt‐Hale · correspondingTufts University; Agricultural Research Service
Abstract
Berry fruits contain a variety of bioactive polyphenolic compounds that exhibit potent antioxidant and anti-inflammatory activities. We have shown that consumption of freeze-dried whole berry powder, equivalent to 1 cup per day of blueberry (BB) or 2 cups per day of strawberry (SB), can differentially improve some aspects of cognition in healthy, older adults, compared to placebo-supplemented controls. We investigated whether fasting and postprandial serum from BB- or SB-supplemented older adults (60-75 years), taken at baseline or after 45 or 90 days of supplementation, would reduce the production of inflammatory and oxidative stress markers compared to serum from a placebo group, in LPS-stressed HAPI rat microglial cells, in vitro. Serum from both BB- and SB-supplemented participants reduced nitrite production, iNOS and COX-2 expression, and TNF-alpha release relative to serum from placebo controls (p < 0.05). Protection was greatest with serum from the 90-day time-point, suggesting that ongoing supplementation may provide the most health benefits. Serum was protective in both fasted and postprandial conditions, indicating that the effects are not only acute and that the meal did not challenge subjects' ability to regulate oxidative and inflammatory stress. These results suggest that berry metabolites, present in the circulating blood following ingestion, may be mediating the anti-inflammatory effects of dietary berry fruit.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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