Association of magnesium consumption with type 2 diabetes and glucose metabolism: A systematic review and pooled study with trial sequential analysis
Zhao B, Deng H, Li B, Chen L, Zou F, Hu L, Wei Y, Zhang W
Diabetes/metabolism research and reviews · 24 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Grants
- National Natural Science Foundation of China (81560345)
Based on 1 listed funder(s).
Publication
- Published
- 2019-11-23 · Diabetes Metab Res Rev · vol. 36 · issue 3 · p. e3243
- Publisher
- Wiley
- Cited
- 34 citations · more than 63% of similar papers · 0.7× the field average
- References
- 65 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease · Therapeutic Uses of Natural Elements · Parathyroid Disorders and Treatments
- Keywords
- Type 2 diabetes, Medicine, Diabetes mellitus, Magnesium, Internal medicine, Endocrinology, Chemistry
- MeSH
- humans, diabetes mellitus, type 2, magnesium, blood glucose, glucose tolerance test, fasting, dietary supplements
8 authors
From CN
- Binghao ZhaoNanchang University; Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital; Second Affiliated Hospital of Nanchang University
- Huan DengNanchang University; First Affiliated Hospital of Jiangxi Medical College; Second Affiliated Hospital of Nanchang University
- Bo LiNanchang University; First Affiliated Hospital of Jiangxi Medical College; Second Affiliated Hospital of Nanchang University
- Chen LianNanchang University; First Affiliated Hospital of Jiangxi Medical College; Second Affiliated Hospital of Nanchang University
- Fang ZouNanchang University; Second Affiliated Hospital of Nanchang University
- Lei HuNanchang University; Second Affiliated Hospital of Nanchang University
Abstract
Prevention of type 2 diabetes (T2D) with diet or diet supplementation is challenging. This article aims to draw conclusive associations between magnesium intake and T2D incidence and evaluate the effect of magnesium supplementation on glucose metabolism. Databases were searched for related articles from inception to May 15, 2019. Prospective cohort studies investigating the relevant relationship as well as randomized controlled trials (RCTs) assessing the effect of magnesium supplementation were eligible. We conducted trial sequential analysis (TSA) to prove the sufficiency of the current evidence. Twenty-six publications involving 35 cohorts were included in the analysis. Compared to the lowest magnesium intake, the highest level was associated with a 22% lower risk for T2D; the risk was reduced by 6% for each 100 mg increment in daily magnesium intake. Additional analysis of 26 RCTs (1168 participants) was performed, revealing that magnesium supplementation significantly reduced the fasting plasma glucose (FPG) level (SMD, -0.32 [95% CI, -0.59 to -0.05], 2-hour oral glucose tolerance test (2-h OGTT) result (SMD, -0.30 [-0.58 to -0.02]), fasting insulin level (SMD, -0.17 [-0.30 to -0.04]), homeostatic model assessment-insulin resistance (HOMA-IR) score (SMD, -0.41 [-0.71 to -0.11]), triglyceride (TG) level, systolic blood pressure (SBP) and diastolic blood pressure (DBP). TSA showed an inverse association, with most benefits of magnesium supplementation on glucose metabolism being stable. In conclusion, magnesium intake has an inverse dose-response association with T2D incidence, and supplementation appears to be advisable in terms of glucose parameters in T2D/high-risk individuals.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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