Threshold-Effect Association of Dietary Cholesterol Intake with Dyslipidemia in Chinese Adults: Results from the China Health and Nutrition Survey in 2015
Huang Q, Jiang H, Zhang B, Wang H, Jia X, Huang F, Wang L, Wang Z
Nutrients · 22 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Government
- the National Institute for Nutrition and Health, China Center for Disease Control and Prevention; Carolina Population Center
- Government
- NICHD NIH HHS
- Government
- the Ministry of Finance of the People's Republic of China, the China Nutritional Transition Cohort Study
- Government
- the Fogarty International Center, National Institutes of Health
- Government
- NIH HHS
- Grants
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD030880); National Institutes of Health (R24 HD‐050924); National Institutes of Health (R01- HD38700); National Institutes of Health (R01 HD30880); National Institutes of Health (DK-056350); National Institutes of Health (R01-HD30880, DK056350, R24 HD050924, R01-HD38700)
Based on 7 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-11-27 · Nutrients · vol. 11 · issue 12 · p. 2885
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 31 citations · more than 91% of similar papers · 3.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 36 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Lipoproteins and Cardiovascular Health · Cancer, Lipids, and Metabolism · Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- Dyslipidemia, Medicine, Hypertriglyceridemia, Cholesterol, Internal medicine, National Health and Nutrition Examination Survey, Hypocholesterolemia, Clinical nutrition, Endocrinology, Triglyceride, Obesity, Environmental health, Population
- MeSH
- humans, hypercholesterolemia, hypertriglyceridemia, cholesterol, dietary, nutrition surveys, odds ratio, adolescent, adult, middle aged, diet records, china, dyslipidemias, cholesterol, ldl, cholesterol, hdl, young adult, asian people
8 authors
From CN
- Qiumin HuangChinese Center For Disease Control and Prevention; National Institute for Nutrition and Health
- Hongru JiangChinese Center For Disease Control and Prevention; National Institute for Nutrition and Health
- Bing ZhangChinese Center For Disease Control and Prevention; National Institute for Nutrition and Health
- Huijun WangChinese Center For Disease Control and Prevention; National Institute for Nutrition and Health
- Xiaofang JiaChinese Center For Disease Control and Prevention; National Institute for Nutrition and Health
- Feifei HuangChinese Center For Disease Control and Prevention; National Institute for Nutrition and Health
Abstract
The association of dietary cholesterol intake with dyslipidemia and subtypes is controversial. This study aimed to examine the association of dietary cholesterol intake with dyslipidemia and subtypes in Chinese adults. Using data from the China Health and Nutrition Survey (CHNS) in 2015, the present study selected 4383 participants aged 18-59 years who were free of diabetes, apoplexy, and myocardial infarction disease. Information was obtained on dietary intake, anthropometric measurements, and blood laboratory measurements. Dietary cholesterol intake was calculated based on the data collected by consecutive 3 days 24 h recalls combined with the weighing of household seasonings and categorized by 11 levels: The first 10 levels in ranges of 50 mg/day and the 11th level at ≥500 mg/day. Dyslipidemia, hypercholesterolemia, hypertriglyceridemia, low-density lipoprotein (LDL)-hypercholesterolemia, and high-density lipoprotein (HDL)-hypocholesterolemia were defined based on the Chinese adult dyslipidemia prevention guide (2016 edition). Multivariable logistic regressions were performed to examine the association of dietary cholesterol intake levels with dyslipidemia and subtypes. The prevalence of dyslipidemia was 37.5% among Chinese adults in 2015 (hypercholesterolemia 9.6%, HDL-hypocholesterolemia 21.1%, LDL-hypercholesterolemia 12.7%, and hypertriglyceridemia 15.2%). The lowest prevalence of hypercholesterolemia and LDL-hypercholesterolemia was 6.7% and 9.4%, respectively, which was relative to a dietary cholesterol intake level of 100.0 to <150.0 mg/day. After adjusting for all potential confounders, adults with the highest dietary cholesterol intake level of ≥500 mg/day compared with the dietary cholesterol intake of 100.0 to <150.0 mg/day showed one-time higher odds of hypercholesterolemia (odds ratios (OR) 2.0, 95% confidence intervals (CI) 1.3-3.3), as well as LDL-hypercholesterolemia (OR 2.0, 95% CI 1.3-3.0), but a null association of dietary cholesterol intake with dyslipidemia, hypertriglyceridemia, and HDL-hypocholesterolemia. The study suggested that a dietary cholesterol intake level of 500 mg/day and above may be a threshold point for high odds of hypercholesterolemia and LDL-hypercholesterolemia.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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