The Impact of Genetic Variations in ADORA2A in the Association between Caffeine Consumption and Sleep
Erblang M, Drogou C, Gomez-Merino D, Metlaine A, Boland A, Deleuze JF, Thomas C, Sauvet F, Chennaoui M
Genes · 38 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Délégation Générale pour l'Armement
- Government
- Direction Générale de l’Armement
- Government
- Délégation Générale pour l'Armement
- Grants
- Délégation Générale pour l'Armement (PDH-1-SMO-2-509)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-12-06 · Genes (Basel) · vol. 10 · issue 12 · p. 1021
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 49 citations · more than 93% of similar papers · 3.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Coffee research and impacts · Sleep and related disorders · Eating Disorders and Behaviors
- Keywords
- Caffeine, Single-nucleotide polymorphism, Insomnia, Allele, Medicine, Internal medicine, Linkage disequilibrium, Odds ratio, SNP, Haplotype, Polymorphism (computer science), Endocrinology, Genotype, Genetics, Biology, Psychiatry, Gene
- MeSH
- humans, sleep initiation and maintenance disorders, caffeine, receptor, adenosine a2a, sleep, linkage disequilibrium, polymorphism, single nucleotide, alleles, adolescent, adult, middle aged, female, male
9 authors
From FR
- Mégane ErblangUniversité Paris Cité; Sommeil, vigilance, fatigue et santé publique
- Catherine DrogouUniversité Paris Cité; Sommeil, vigilance, fatigue et santé publique
- Danielle Gomez-MérinoUniversité Paris Cité; Sommeil, vigilance, fatigue et santé publique
- Arnaud MetlaineUniversité Paris Cité; Assistance Publique – Hôpitaux de Paris; Hôtel-Dieu de Paris; Sommeil, vigilance, fatigue et santé publique
- Anne BolandCommissariat à l'Énergie Atomique et aux Énergies Alternatives; Université Paris-Saclay; Centre National de Recherche en Génomique Humaine; CEA Paris-Saclay - Etablissement de Fontenay-aux-roses; Direction de la Recherche Fondamentale; CEA Paris-Saclay; Institut de biologie François Jacob
- Jean‐François DeleuzeCommissariat à l'Énergie Atomique et aux Énergies Alternatives; Université Paris-Saclay; Centre National de Recherche en Génomique Humaine; CEA Paris-Saclay - Etablissement de Fontenay-aux-roses; Direction de la Recherche Fondamentale; CEA Paris-Saclay; Institut de biologie François Jacob
Abstract
ADORA2A has been shown to be responsible for the wakefulness-promoting effect of caffeine and the 1976T>C genotype (SNP rs5751876, formerly 1083T>C) to contribute to individual sensitivity to caffeine effects on sleep. We investigate the association between six single nucleotide polymorphisms (SNP) from ADORA2A and self-reported sleep characteristics and caffeine consumption in 1023 active workers of European ancestry aged 18-60 years. Three groups of caffeine consumers were delineated: low (0-50 mg/day, less than one expresso per day), moderate (51-300 mg/day), and high (>300 mg/day). We found that at caffeine levels higher than 300 mg/day, total sleep time (TST) decreased (F = 13.9, p p < 0.05). These 4 SNPs are in strong linkage disequilibrium. Haplotype analysis confirmed the influence of multiple ADORA2a SNPs on TST. In addition, the rs2298383 T and rs4822492 G alleles were associated with higher risk of sleep complaints (Ora = 1.9 [1.2-3.1] and Ora = 1.5 [1.1-2.1]) and insomnia (Ora = 1.5 [1.3-2.5] and Ora = 1.9 [1.3-3.2). The rs5751876 T allele was associated with a decreased risk of sleep complaints (Ora = 0.7 [0.3-0.9]) and insomnia (Ora = 0.5 [0.3-0.9]). Our results identified ADORA2A polymorphism influences in the less-than-300-mg-per-day caffeine consumers. This opens perspectives on the diagnosis and pharmacology of sleep complaints and caffeine chronic consumption.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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