The effect of canola oil compared with sesame and sesame-canola oil on cardio-metabolic biomarkers in patients with type 2 diabetes: Design and research protocol of a randomized, triple-blind, three-way, crossover clinical trial
Amiri M, Ghaneian MT, Zare-Sakhvidi MJ, Rahmanian M, Nadjarzadeh A, Moghtaderi F, Raeisi-Dehkordi H, Zimorovat A, Jafari F, Zavar-Reza J, Jahan-Mihan A, Reza Aghaei-Meybodi M, Salehi-Abargouei A
ARYA atherosclerosis · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
Based on full-text disclosure statement.
Publication
- Published
- 2019-07-01 · ARYA Atheroscler · vol. 15 · issue 4 · pp. 168–178
- Publisher
- National Institutes of Health
- Cited
- 15 citations · more than 80% of similar papers · 1.5× the field average
- References
- 49 works
- Access
- Open access (repository copy) · CC-BY-NC
- Research areas
- Fatty Acid Research and Health · Sesame and Sesamin Research · Diet and metabolism studies
- Keywords
- Canola, Medicine, Triglyceride, Sesame oil, Crossover study, Cholesterol, Internal medicine, Food science, Biology, Sesamum, Agronomy
13 authors
From IR, US
- Mojgan AmiriShahid Sadoughi University of Medical Sciences and Health Services
- Mohammad Taghi GhaneianShahid Sadoughi University of Medical Sciences and Health Services
- Mohammad Javad Zare SakhvidiShahid Sadoughi University of Medical Sciences and Health Services
- Masoud RahmanianShahid Sadoughi University of Medical Sciences and Health Services
- Azadeh NadjarzadehShahid Sadoughi University of Medical Sciences and Health Services
- Fatemeh MoghtaderiShahid Sadoughi University of Medical Sciences and Health Services
Abstract
Background
Both canola and sesame oils consumption have been associated with favorable effects on cardio-metabolic biomarkers. However, to the best of our knowledge, no study has compared their effects on cardiovascular risk factors. The present study aimed to assess the effect of canola, sesame, and sesame-canola oils consumption on cardio-metabolic biomarkers in patients with type 2 diabetes mellitus (T2DM).
Methods
This study was a randomized, triple-blind, three-way, crossover clinical trial. The study participants included 102 individuals with T2DM. Their spouses were also included in the study. The participants were entered into a 4-week run-in period. After that, their regular dietary oil was replaced with canola, sesame, or sesame-canola oils (a blend of sesame and canola oils) in three 9-week phases, which were separated by two 4-week washout periods (sunflower oil was consumed during the run-in and the washout periods). Dietary, physical activity, blood pressure, and anthropometric measurements were assessed at the beginning, in the middle (week 4-5), and at the end of each treatment phase. Blood samples were taken at the beginning and at the end of each phase. Serum, plasma, buffy coat, and whole blood samples were extracted and kept at -80 ºC for further analysis. Serum fasting blood sugar (FBS), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were selected as the primary outcomes.
Results
102 participants with T2DM were randomly assigned to one of the 6 rolling methods. Through them, 93 individuals (91.2%) completely participated in all phases.
Conclusion
The present study will provide an exceptional opportunity to examine the effect of canola, sesame, and sesame-canola oil on cardio-metabolic markers in adults with and without T2DM. This trial will also provide a good medium for the investigation of gene-dietary oils interaction in the future.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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