Age and Muscle Function Are More Closely Associated With Intracellular Magnesium, as Assessed by 31P Magnetic Resonance Spectroscopy, Than With Serum Magnesium
Cameron D, Welch AA, Adelnia F, Bergeron CM, Reiter DA, Dominguez LJ, Brennan NA, Fishbein KW, Spencer RG, Ferrucci L
Frontiers in physiology · 23 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of East Anglia
- Government
- National Institutes of Health
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-11-26 · Front Physiol · vol. 10 · p. 1454
- Publisher
- Frontiers Media
- Cited
- 29 citations · more than 82% of similar papers · 1.7× the field average
- References
- 53 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Therapeutic Uses of Natural Elements · Parathyroid Disorders and Treatments
- Keywords
- Magnesium, Intracellular, Magnetic resonance imaging, Nuclear magnetic resonance, Resonance (particle physics), Function (biology), Nuclear magnetic resonance spectroscopy, Chemistry, Internal medicine, Medicine, Endocrinology, Biophysics, Biochemistry, Biology, Physics, Cell biology, Atomic physics, Radiology
10 authors
From GB, US, IT
- Donnie Cameron · correspondingUniversity of East Anglia; National Institutes of Health; Institute on Aging; National Institute on Aging
- Ailsa A. WelchUniversity of East Anglia
- Fatemeh AdelniaNational Institutes of Health; Institute on Aging; National Institute on Aging
- Christopher M. BergeronNational Institutes of Health; Institute on Aging; National Institute on Aging
- David A. ReiterEmory University
- Ligia Juliana DominguezUniversity of Palermo
Abstract
Total serum magnesium is a common clinical measurement for assessing magnesium status; however, magnesium in blood represents less than 1% of the body's total magnesium content. We measured intramuscular ionized magnesium by phosphorus magnetic resonance spectroscopy (31P-MRS) and tested the hypothesis that this measure better correlates with skeletal muscle function and captures more closely the effect of aging than the traditional measure of total serum magnesium. Data were collected from 441 participants (age 24-98 years) in the Baltimore Longitudinal Study of Aging (BLSA), a study of normative aging that encompasses a broad age range. Results showed that intramuscular ionized magnesium was negatively associated with age (β = -0.29, p R 2 = 0.08) and positively associated with knee-extension strength (β = 0.31, p R 2 = 0.1 in women; and β = 0.2, p = 0.003, and R 2 = 0.04 in men), while total serum magnesium showed no association with age or strength (p = 0.27 and 0.1, respectively). Intramuscular ionized magnesium was significantly lower in women that in men (p 31P-MRS is a better clinical measure of magnesium status than total serum magnesium, and could be measured when muscle weakness of unidentified etiology is detected. It may also be used to monitor the effectiveness of oral magnesium interventions, including supplementation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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