Association of Dietary Magnesium Intake with Fatal Coronary Heart Disease and Sudden Cardiac Death
Li J, Hovey KM, Andrews CA, Quddus A, Allison MA, Van Horn L, Martin LW, Salmoirago-Blotcher E, Song Y, Manson JE, Albert CM, Lu B, Eaton CB
Journal of women's health (2002) · 6 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Heart, Lung, and Blood Institute
- Government
- NHLBI NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (HHSN268201600018C); National Heart, Lung, and Blood Institute (HHSN268201600004C); National Heart, Lung, and Blood Institute (HHSN268201600001C); National Heart, Lung, and Blood Institute (R01HL091069); National Heart, Lung, and Blood Institute (HHSN268201600003C); National Heart, Lung, and Blood Institute (HHSN268201600002C)
Based on 2 listed funder(s).
Publication
- Published
- 2019-12-12 · J Womens Health (Larchmt) · vol. 29 · issue 1 · pp. 7–12
- Publisher
- Mary Ann Liebert, Inc.
- Cited
- 10 citations · more than 66% of similar papers · 0.5× the field average
- References
- 31 works
- Access
- Open access (repository copy)
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments
- Keywords
- Medicine, Quartile, Hazard ratio, Sudden cardiac death, Confidence interval, Internal medicine, Confounding, Cause of death, Population, Cardiology, Disease, Environmental health
- MeSH
- humans, death, sudden, cardiac, coronary disease, magnesium, proportional hazards models, risk factors, cohort studies, prospective studies, risk reduction behavior, nutritional status, postmenopause, aged, middle aged, united states, female, surveys and questionnaires
13 authors
From US
- Jason LiBrown University; Memorial Hospital of Rhode Island
- Kathleen M. O'Reilly HoveyUniversity at Buffalo, State University of New York
- Chris AndrewsUniversity of Michigan
- Abdullah QuddusSt. Luke's University Health Network
- Matthew AllisonUniversity of California San Diego
- Linda Van HornNorthwestern University
Abstract
Background: Postmenopausal women represent the highest population-based burden of cardiovascular disease, including sudden cardiac death (SCD). Our understanding of the etiology and risk factors contributing to fatal coronary heart disease (CHD) and SCD, particularly among women, is limited. This study examines the association between dietary magnesium intake and fatal CHD and SCD. Materials and Methods: We examined 153,569 postmenopausal women who participated in the Women's Health Initiative recruited between 1993 and 1998. Magnesium intake at baseline was assessed using a validated food frequency questionnaire, adjusting for energy via the residual method. Fatal CHD and SCD were identified over an average follow-up of 10.5 years. Results: For every standard deviation increase in magnesium intake, there was statistically significant risk reduction, after adjustment for confounders, of 7% for fatal CHD (hazard ratio [HR] 0.93, 95% confidence interval [CI] 0.89-0.97), and 18% risk reduction for SCD (HR 0.82, 95% CI 0.58-1.15) the latter of which did not reach statistical significance. In age-adjusted quartile analysis, women with the lowest magnesium intake (189 mg/day) had the greatest risk for fatal CHD (HR 1.54, 95% CI 1.40-1.69) and SCD (HR 1.70, 95% CI 0.94-3.07). This association was attenuated in the fully adjusted model, with HRs of 1.19 (95% CI 1.06-1.34) for CHD and 1.24 (95% CI 0.58-2.65) for SCD for the lowest quartile of magnesium intake. Conclusions: This study provides evidence of a potential inverse association between dietary magnesium and fatal CHD and a trend of magnesium with SCD in postmenopausal women. Future studies should confirm this association and consider clinical trials to test whether magnesium supplementation could reduce fatal CHD in high-risk individuals.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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