Islamic fasting leads to an increased abundance of Akkermansia muciniphila and Bacteroides fragilis group: A preliminary study on intermittent fasting
Özkul C, Yalınay M, Karakan T
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 72 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-12-11 · Turk J Gastroenterol · vol. 30 · issue 12 · pp. 1030–1035
- Cited
- 104 citations · more than 95% of similar papers · 4.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 41 works
- Access
- Free to read
- Research areas
- Dietary Effects on Health · Gut microbiota and health · Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Akkermansia muciniphila, Bacteroides fragilis, Faecalibacterium prausnitzii, Akkermansia, Medicine, Gut flora, Bifidobacterium, Physiology, Feces, Bacteroides, Internal medicine, Lactobacillus, Microbiology, Gastroenterology, Biology, Food science, Immunology, Bacteria, Antibiotics
- MeSH
- humans, bacteroides fragilis, fasting, pilot projects, time factors, islam, adult, middle aged, female, male, verrucomicrobia, gastrointestinal microbiome, akkermansia
3 authors
From TR
- Ceren ÖzkulHacettepe University
- Meltem YalınayGazi University
- Tarkan KarakanGazi University
Abstract
Background/aims
It has been largely accepted that dietary habits affect intestinal microbiota composition. In this pilot study, we hypothesized that time-restricted feeding, which can be regarded as a type of intermittent fasting, may have a distinct effect on intestinal microbiota. Ramadan fasting is an excellent model to understand how time-restricted feeding affect the microbiota.
Materials and methods
A total of nine subjects were included in this study during Ramadan, consisting of 17 h of fasting/day during a 29-day period. Stool samples were collected at baseline and the day of the end of Ramadan. 16S rRNA qPCR assay has been performed for quantification of Akkermansia muciniphila, Faecalibacterium prausnitzii, Bifidobacterium spp., Lactobacillus spp., Bacteroides fragilis group, and Enterobacteriaceae. Blood samples were also collected to test for metabolic and nutritional parameters.
Results
A significantly increased abundance of A. muciniphila and B. fragilis group was observed in all subjects after Islamic fasting when compared with the baseline levels (p=0.004 and 0.008, respectively). Serum fasting glucose and total cholesterol levels were also significantly reduced in all of the subjects (p<0.01 and p=0.009, respectively).
Conclusion
Islamic fasting, which represents intermittent fasting, leads to an increase in A. muciniphila and B. fragilis group, which were considered as healthy gut microbiota members. Although this is a pilot study, which should be tested with larger sample size, there are a very limited number of studies in the literature on fasting and microbiota in human subjects. Thus, our present findings may contribute to the understanding of fasting-gut microbiota interaction.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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