Effect of time-restricted feeding on metabolic risk and circadian rhythm associated with gut microbiome in healthy males
Zeb F, Wu X, Chen L, Fatima S, Haq IU, Chen A, Majeed F, Feng Q, Li M
The British journal of nutrition · 146 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- China Scholarship Council
- Government
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Based on 2 listed funder(s).
Publication
- Published
- 2020-01-06 · Br J Nutr · vol. 123 · issue 11 · pp. 1216–1226
- Publisher
- Cambridge University Press
- Cited
- 199 citations · more than 99% of similar papers · 11.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Free to read
- Research areas
- Dietary Effects on Health · Gut microbiota and health · Diet and metabolism studies
- Keywords
- Circadian rhythm, Biology, Microbiome, Gut flora, Gene, Endocrinology, Internal medicine, Genetics, Immunology, Medicine
- MeSH
- liver, humans, metabolic diseases, genetic predisposition to disease, lipids, bacterial proteins, rna, ribosomal, 16s, fasting, circadian rhythm, adult, male, young adult, healthy volunteers, biomarkers, gastrointestinal microbiome, cardiometabolic risk factors
9 authors
From CN, PK
- Falak ZebNanjing Medical University
- Xiaoyue WuNanjing Medical University
- Lijun ChenNanjing Medical University
- Sadia FatimaKhyber Medical University
- Ijaz-ul HaqNanjing Medical University
- Aochang ChenNanjing Medical University
Abstract
Time-restricted feeding (TRF) confers protection against nutritional challenges that predispose obesity and metabolic risks through involvement of circadian locomotor output cycles protein kaput genes and gut microbiome, but the underlying mechanism is not clearly understood. Therefore, the present study examined the effects of TRF on metabolic markers and circadian rhythm associated with gut microbiota in healthy males. Two groups (TRF, n 56; non-TRF, n 24) of male adults were enrolled. The TRF group provided blood at pre-TRF and post-TRF, while non-TRF one time after 25 d of trial. Serum lipid and liver profiles were determined. Real time-PCR was applied for circadian and inflammatory gene expression. The 16S rRNA genes were sequenced on the Illumina Miseq v3 platform to comprehensively catalogue the composition and abundance of bacteria in stool. We showed that TRF ameliorated the serum lipid and liver profiles of the individuals. In the TRF group, gut microbial richness was significantly enhanced, with enrichment of Prevotellaceae and Bacteroideaceae. TRF enhanced circadian gene expression probably by activation of sirtuin-1, which is positively associated with gut microbiome richness. TRF could be a safe remedy for the prevention of metabolic diseases related to dyslipidaemia, as it regulates circadian rhythm associated with gut microbiome modulation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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