Developmental changes of caffeine elimination in infancy
Pons G, Carrier O, Richard MO, Rey E, d'Athis P, Moran C, Badoual J, Olive G
Developmental pharmacology and therapeutics · 30 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-08-11 · Dev Pharmacol Ther · vol. 11 · issue 5 · pp. 258–264
- Publisher
- Karger Publishers
- Cited
- 51 citations · more than 70% of similar papers · 0.8× the field average
- References
- 0 works
- Access
- Paywalled
- Research areas
- Coffee research and impacts · Breastfeeding Practices and Influences · Child Nutrition and Feeding Issues
- Keywords
- Caffeine, Medicine, Biology, Endocrinology
- MeSH
- humans, apnea, infant, premature, diseases, caffeine, drug administration schedule, aging, gestational age, half-life, infant, infant, newborn
8 authors
From FR
- Gérard PonsUniversité Paris Cité; Hôpital Saint-Vincent-de-Paul
- Odile CarrierUniversité Paris Cité; Hôpital Saint-Vincent-de-Paul
- Marie‐Odile RichardUniversité Paris Cité; Hôpital Saint-Vincent-de-Paul
- Elisabeth ReyUniversité Paris Cité; Hôpital Saint-Vincent-de-Paul
- Philippe d’AthisDépartement d'Informatique
- Claude MoranUniversité Paris Cité; Hôpital Saint-Vincent-de-Paul
Abstract
Five neonates (4 premature) and 16 infants (6 prematurely born), 15-588 days old, received caffeine as citrate salt for apnea. Plasma samples were collected 0, 2, 4, 6 h after a dose and before the next scheduled one. Patients 8 and 9 were serially studied. Caffeine plasma concentrations were determined using HPLC. The caffeine elimination half-life and clearance varied linearly with gestational age and exponentially with postnatal age, the plateau being reached during the second trimester of life. Dose regimen guidelines as a function of postnatal age were derived from individually calculated doses and dosing intervals in order to achieve, at steady state, a caffeine mean plasma concentration of 11 mg/l with a minimum of 7.5 mg/l and a maximum of 14.5 mg/l. We suggest dosing intervals for infants before 1 month, 1-2 months, 2-4 months and after 4 months to be equal to 24, 12, 8 and 6 h, respectively. The individual recommended dose varies from 2 to 10 mg/kg (as caffeine base) making caffeine monitoring mandatory in infants.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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