CD137 negatively affects "browning" of white adipose tissue during cold exposure
Srivastava RK, Moliner A, Lee ES, Nickles E, Sim E, Liu C, Schwarz H, Ibáñez CF
The Journal of biological chemistry · 19 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Medical Research Council
- Government
- MOH | National Medical Research Council
- Grants
- National Medical Research Council (NMRC2016-LKUI); National Medical Research Council (NMRC2018-hJET)
Based on 2 listed funder(s).
Publication
- Published
- 2020-01-10 · J Biol Chem · vol. 295 · issue 7 · pp. 2034–2042
- Publisher
- Elsevier BV
- Cited
- 27 citations · more than 85% of similar papers · 1.8× the field average
- References
- 21 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Adipose Tissue and Metabolism · Exercise and Physiological Responses · Cardiovascular Disease and Adiposity
- Keywords
- White adipose tissue, Thermogenin, Adipose tissue, PRDM16, Thermogenesis, Adipocyte, Internal medicine, Endocrinology, Brown adipose tissue, Biology, FGF21, Cell biology, Fibroblast growth factor, Receptor, Medicine
- MeSH
- animals, mice, knockout, humans, mice, body temperature, gene expression regulation, thermogenesis, adipose tissue, brown, adipose tissue, white, cold temperature, uncoupling protein 1, adipocytes, beige, tumor necrosis factor receptor superfamily, member 9
8 authors
From SG, SE, ZA
- Raj Kamal SrivastavaNational University of Singapore; Life Sciences Institute
- Annalena MolinerNational University of Singapore; Karolinska Institutet; National Neuroscience Institute; Life Sciences Institute
- Ee Soo LeeNational University of Singapore; Life Sciences Institute
- Emily Pauline NicklesNational University of Singapore; Life Sciences Institute
- Eunice Weiling SimNational University of Singapore; Life Sciences Institute
- Chang LiuNational University of Singapore; Life Sciences Institute
Abstract
Prolonged cold exposure stimulates the formation of brownlike adipocytes expressing UCP1 (uncoupling-protein-1) in subcutaneous white adipose tissue which, together with classical brown adipose tissue, contributes to maintaining body temperature in mammals through nonshivering thermogenesis. The mechanisms that regulate the formation of these cells, alternatively called beige or brite adipocytes, are incompletely understood. Here we report that mice lacking CD137, a cell surface protein used in several studies as a marker for beige adipocytes, showed elevated levels of thermogenic markers, including UCP1, increased numbers of beige adipocyte precursors, and expanded UCP1-expressing cell clusters in inguinal white adipose tissue after chronic cold exposure. CD137 knockout mice also showed enhanced cold resistance. These results indicate that CD137 functions as a negative regulator of "browning" in white adipose tissue and call into question the use of this protein as a functional marker for beige adipocytes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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