Biological Responses of Stem Cells to Photobiomodulation Therapy
Khorsandi K, Hosseinzadeh R, Abrahamse H, Fekrazad R
Current stem cell research & therapy · 37 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-02-04 · Curr Stem Cell Res Ther · vol. 15 · issue 5 · pp. 400–413
- Publisher
- Bentham Science Publishers
- Cited
- 53 citations · more than 92% of similar papers · 2.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 111 works
- Access
- Paywalled
- Research areas
- Laser Applications in Dentistry and Medicine · Medical and Biological Ozone Research · Photodynamic Therapy Research Studies
- Keywords
- Stem cell, Regenerative medicine, Stem-cell therapy, Medicine, Adenosine triphosphate, Cell therapy, Mitochondrion, Cell biology, Reactive oxygen species, Mitochondrial respiratory chain, Induced pluripotent stem cell, Chemistry, Biology, Biochemistry, Internal medicine
- MeSH
- stem cells, animals, humans, regenerative medicine, signal transduction, low-level light therapy
4 authors
From IR, ZA
- Khatereh KhorsandiAcademic Center for Education, Culture and Research; Universal Scientific Education and Research Network
- Reza Hosseinzadeh
- Heidi AbrahamseUniversity of Johannesburg
- Reza Fekrazad · correspondingAja University of Medical Sciences
Abstract
Background
Stem cells have attracted the researchers interest, due to their applications in regenerative medicine. Their self-renewal capacity for multipotent differentiation, and immunomodulatory properties make them unique to significantly contribute to tissue repair and regeneration applications. Recently, stem cells have shown increased proliferation when irradiated with low-level laser therapy or Photobiomodulation Therapy (PBMT), which induces the activation of intracellular and extracellular chromophores and the initiation of cellular signaling. The purpose of this study was to evaluate this phenomenon in the literature.
Methods
The literature investigated the articles written in English in four electronic databases of PubMed, Scopus, Google Scholar and Cochrane up to April 2019. Stem cell was searched by combining the search keyword of "low-level laser therapy" OR "low power laser therapy" OR "low-intensity laser therapy" OR "photobiomodulation therapy" OR "photo biostimulation therapy" OR "LED". In total, 46 articles were eligible for evaluation.
Results
Studies demonstrated that red to near-infrared light is absorbed by the mitochondrial respiratory chain. Mitochondria are significant sources of reactive oxygen species (ROS). Mitochondria play an important role in metabolism, energy generation, and are also involved in mediating the effects induced by PBMT. PBMT may result in the increased production of (ROS), nitric oxide (NO), adenosine triphosphate (ATP), and cyclic adenosine monophosphate (cAMP). These changes, in turn, initiate cell proliferation and induce the signal cascade effect.
Conclusion
The findings of this review suggest that PBMT-based regenerative medicine could be a useful tool for future advances in tissue engineering and cell therapy.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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