Magnesium Supplementation did not affect the Antiseizure Property of Ketogenic Diet but Reduced Lipid Dysmetabolism
Sanya EO, Adeyanju OA, Olarinoye JK, Bello H, Alaofin WA, Wahab KW, Soladoye AA
West African journal of medicine · 1 citation
Review labels
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How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-03-06 · West Afr J Med · vol. 37 · issue 1 · pp. 7–12
- Publisher
- National Institutes of Health
- Cited
- 1 citation · more than 41% of similar papers · 0.1× the field average
- References
- 0 works
- Access
- Paywalled
- Research areas
- Diet and metabolism studies · Metabolism and Genetic Disorders · Diet, Metabolism, and Disease
- Keywords
- Ketogenic diet, Medicine, Epilepsy, Internal medicine, Endocrinology, Magnesium, Dyslipidemia, Disease, Chemistry
- MeSH
- animals, humans, rats, rats, sprague-dawley, rats, wistar, seizures, disease models, animal, magnesium, pentylenetetrazole, lipids, dietary supplements, male, lipid metabolism, diet, ketogenic
7 authors
From NG
- EO SanyaUniversity of Ilorin
- Oluwaseun Aremu AdeyanjuUniversity of Ilorin; Kwara State University
- J K Olarinoye
- H BelloUniversity of Ilorin; Kwara State Polytechnic; Kwara State University
- Wemimo A. AlaofinUniversity of Ilorin; Kwara State Polytechnic; Kwara State University
- Kolawole WahabUniversity of Ilorin; Kwara State Polytechnic; Kwara State University
Abstract
Background
Ketogenic diets (KD) have been used globally in epilepsy management. Similarly, supplementation of diets with magnesium has been associated with disease prevention and improvement. However, the effect of magnesium (Mg) supplementation in conjunction with KD on epilepsy has not yet been investigated. We hypothesized that magnesium supplementation in KD would improve the effectiveness of the diet.
Methods
Forty-eight male Wistar rats were used for the study. The animals were fed on 4 diet types: I-normal rat chow (ND), II-ND with Mg supplement (ND+Mg), III-medium chain ketogenic diet (KD) and IV-KD with Mg supplement (KD+Mg). Animals in each group were divided into 3: experimental, control and observatory. The experimental drug was intraperitoneal Pentylenetetrazole (PTZ) administered at 25 mg/kg. The rats were observed for 2 hours after the drug administration and induced seizures noted. The levels of serum electrolytes and plasma lipid levels were determined using standard methods.
Results
The seizure latency was significantly prolonged 60.8±0.5mins in group III compared with 8.7±2.1mins in group I (p<0.05). The seizure duration was 42.5±2.5mins in group III and 142.3±4.7 in group I (p<0.05). With Mg supplementation, seizure latency was 62.6±1.5mins in group IV and 7.9±0.7mins in group I (p<0.05). The seizure duration was 45.5±4.5min in group IV and 139.3±3.9mins in group II (p< 0.05). The KD-fed rats showed a tendency to develop dyslipidemia as evidenced by elevated Total Cholesterol /HDL and LDL/HDL (2.32±0.32 and 1.19±0.08) in group III, which was reversed in the KD+Mg fed group IV (1.96±0.32 and 1.08±0.09) with p<0.05.
Conclusion
Mg supplementation of KD did not affect its antiseizure property and does not confer antiseizure effect on ND. Mg supplement showed a tendency to reduce derangement in lipid metabolism associated with KD.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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