Omega-3 fatty acid supplementation in pregnancy-baseline omega-3 status and early preterm birth: exploratory analysis of a randomised controlled trial
Simmonds LA, Sullivan TR, Skubisz M, Middleton PF, Best KP, Yelland LN, Quinlivan J, Zhou SJ, Liu G, McPhee AJ, Gibson RA, Makrides M
BJOG : an international journal of obstetrics and gynaecology · 65 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Thyne Reid Foundation
- Government
- Medical Research Council
- Government
- National Health and Medical Research Council
- Grants
- Thyne Reid Foundation (1,061704); Thyne Reid Foundation (1046207); Thyne Reid Foundation (1052388); National Health and Medical Research Council (1135155); National Health and Medical Research Council (1046207); National Health and Medical Research Council (1052388); National Health and Medical Research Council (1061704); National Health and Medical Research Council (1050468)
Based on 3 listed funder(s).
Publication
- Published
- 2020-02-08 · BJOG · vol. 127 · issue 8 · pp. 975–981
- Publisher
- Wiley
- Cited
- 102 citations · more than 99% of similar papers · 8.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 25 works
- Access
- Free to read
- Research areas
- Preterm Birth and Chorioamnionitis · Fatty Acid Research and Health · Gestational Diabetes Research and Management
- Keywords
- Pregnancy, Omega 3 fatty acid, Omega, Medicine, Randomized controlled trial, Obstetrics, Baseline (sea), Fatty acid, Gynecology, Docosahexaenoic acid, Internal medicine, Physics, Biology, Polyunsaturated fatty acid, Biochemistry
- MeSH
- humans, premature birth, fatty acids, omega-3, pregnancy outcome, prospective studies, gestational age, pregnancy, dietary supplements, adult, infant, newborn, australia, female, randomized controlled trials as topic
12 authors
From AU
- Lucy SimmondsSouth Australian Health and Medical Research Institute
- Thomas SullivanSouth Australian Health and Medical Research Institute
- M. SkubiszWomen's and Children's Hospital; South Australian Health and Medical Research Institute
- P.F. MiddletonSouth Australian Health and Medical Research Institute; The University of Adelaide
- Karen P BestSouth Australian Health and Medical Research Institute; The University of Adelaide
- LN YellandSouth Australian Health and Medical Research Institute; The University of Adelaide
Abstract
Objective
To identify a polyunsaturated fatty acid (PUFA) biomarker able to detect which women with singleton pregnancies are most likely to benefit from omega-3 supplementation to reduce their risk of early preterm birth.
Design
Exploratory analysis of a randomised controlled trial.
Setting
Six Australian hospitals.
Population
Women with a singleton pregnancy enrolled in the ORIP trial.
Methods
Using maternal capillary whole blood collected ~14 weeks' gestation, the fatty acids in total blood lipids were quantified using gas chromatography. Interaction tests examined whether baseline PUFA status modified the effect of omega-3 supplementation on birth outcomes.
Main outcome measure
Early preterm birth (<34 weeks' gestation).
Results
A low total omega-3 PUFA status in early pregnancy was associated with a higher risk of early preterm birth. Among women with a total omega-3 status ≤4.1% of total fatty acids, omega-3 supplementation substantially reduced the risk of early preterm birth compared with control (0.73 versus 3.16%; relative risk = 0.23, 95% confidence interval [CI] 0.07-0.79). Conversely, women with higher total omega-3 status in early pregnancy were at lower risk of early preterm birth. Supplementing women with a baseline status above 4.9% increased early preterm birth (2.20 versus 0.97%; relative risk = 2.27, 95% CI 1.13-4.58).
Conclusions
Women with singleton pregnancies and low total omega-3 PUFA status early in pregnancy have an increased risk of early preterm birth and are most likely to benefit from omega-3 supplementation to reduce this risk. Women with higher total omega-3 status are at lower risk and additional omega-3 supplementation may increase their risk.
Tweetable abstract
Low total omega-3 fat status helps identify which women benefit from extra omega-3 to reduce early prematurity.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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