Inhibitory Effects of Walnut (Juglans regia) Peptides on Neuroinflammation and Oxidative Stress in Lipopolysaccharide-Induced Cognitive Impairment Mice
Wang S, Zheng L, Zhao T, Zhang Q, Liu Y, Sun B, Su G, Zhao M
Journal of agricultural and food chemistry · 94 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-02-09 · J Agric Food Chem · vol. 68 · issue 8 · pp. 2381–2392
- Publisher
- American Chemical Society
- Cited
- 138 citations · more than 98% of similar papers · 7.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 46 works
- Access
- Paywalled
- Research areas
- Biochemical effects in animals · Protein Hydrolysis and Bioactive Peptides · Fatty Acid Research and Health
- Keywords
- Oxidative stress, Proinflammatory cytokine, Inflammation, Lipopolysaccharide, Neuroinflammation, Juglans, Neuroprotection, Chemistry, Pharmacology, Biochemistry, Immunology, Biology
- MeSH
- animals, humans, mice, juglans, nuts, lipopolysaccharides, peptides, neuroprotective agents, anti-inflammatory agents, maze learning, oxidative stress, molecular weight, cognitive dysfunction
8 authors
From CN
- Shuguang WangSouth China University of Technology
- Lin Ping ZhengSouth China University of Technology
- Tiantian ZhaoSouth China University of Technology
- Qi ZhangSouth China University of Technology
- Yang LiuSouth China University of Technology
- Baoguo SunBeijing Technology and Business University; Beijing Advanced Innovation Center for Food Nutrition and Human Health
Abstract
Increasing level of inflammation and oxidative stress could lead to memory impairment. The purpose of this study was to determine the neuroprotective effects of walnut peptides against memory deficits induced by lipopolysaccharide (LPS) in mice and further to explore the underlying anti-inflammatory mechanisms against LPS-elicited inflammation in BV-2 cells. Results showed that walnut protein hydrolysate (WPH) and its low-molecular-weight fraction (WPHL) could ameliorate the memory deficits induced by LPS via normalizing the inflammatory response and oxidative stress in brain, especially WPHL. Furthermore, 18 peptides with anti-inflammatory activities on LPS-activated BV-2 cells were identified from WPHL and it was found that Trp, Gly, and Leu residues in peptides might contribute to the anti-inflammation. Meanwhile, the strong anti-inflammatory effects of LPF, GVYY, and APTLW might be related to their hydrophobic and aromatic amino acid residues as well. LPF, GVYY, and APTLW could reduce the content of proinflammatory mediators and cytokines by downregulating related enzyme expressions and mRNA expressions. Additionally, ROS and mitochondria homeostasis might also contribute to their anti-inflammatory effects.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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