Funded in part by Pfizer, CRIBIQ - Consortium de recherche et innovations en bioprocédés industriels au Québec Fruit d’Or Diana Food Canada Wild Blueberry Association of North America - WBANA
Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice
Rodríguez-Daza MC, Daoust L, Boutkrabt L, Pilon G, Varin T, Dudonné S, Levy É, Marette A, Roy D, Desjardins Y
Scientific reports · 93 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Pfizer
- Government
- Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)
- Government
- Government of Canada
- Government
- Mitacs
- Government
- Canadian Institutes of Health Research
- Government
- CIHR Skin Research Training Centre
- Industry group
- CRIBIQ - Consortium de recherche et innovations en bioprocédés industriels au Québec Fruit d’Or Diana Food Canada Wild Blueberry Association of North America - WBANA
- Government
- CIHR
- Unclassified
- COLCIENCIAS CRIBIQ - Consortium de recherche et innovations en bioprocédés industriels au Québec WBANA- Wild Blueberry Association of North America Diana Food Canada Atrium Innovation Fruit d’Or
- Government
- Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre
- Authors
- At least one author declares a financial tie to industry
Based on 10 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-02-10 · Sci Rep · vol. 10 · issue 1 · p. 2217
- Publisher
- Nature Portfolio
- Cited
- 128 citations · more than 98% of similar papers · 6.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 74 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Gut microbiota and health · Biochemical Analysis and Sensing Techniques · Diet, Metabolism, and Disease
- Keywords
- Phenotype, Proanthocyanidin, Gut flora, Biology, Sucrose, Homeostasis, Glucose homeostasis, Cell biology, Biochemistry, Obesity, Endocrinology, Gene, Polyphenol, Antioxidant
- MeSH
- intestinal mucosa, colon, animals, humans, mice, glucose intolerance, insulin resistance, disease models, animal, proanthocyanidins, dietary sucrose, glucose, blood glucose, plant extracts, administration, oral, male, diet, high-fat, gastrointestinal microbiome, blueberry plants
10 authors
From CA
- Maria-Carolina Rodríguez-DazaUniversité Laval
- Laurence DaoustUniversité Laval
- Lemia BoutkrabtUniversité Laval
- Geneviève PilonInstitut universitaire de cardiologie et de pneumologie de Québec; Université Laval
- Thibault Vincent VarinUniversité Laval
- Stéphanie DudonnéUniversité Laval
Abstract
Blueberries are a rich source of polyphenols, widely studied for the prevention or attenuation of metabolic diseases. However, the health contribution and mechanisms of action of polyphenols depend on their type and structure. Here, we evaluated the effects of a wild blueberry polyphenolic extract (WBE) (Vaccinium angustifolium Aiton) on cardiometabolic parameters, gut microbiota composition and gut epithelium histology of high-fat high-sucrose (HFHS) diet-induced obese mice and determined which constitutive polyphenolic fractions (BPF) was responsible for the observed effects. To do so, the whole extract was separated in three fractions, F1) Anthocyanins and phenolic acids, F2) oligomeric proanthocyanidins (PACs), phenolic acids and flavonols (PACs degree of polymerization DP 4) and supplied at their respective concentration in the whole extract. After 8 weeks, WBE reduced OGTT AUC by 18.3% compared to the HFHS treated rodents and the F3 fraction contributed the most to this effect. The anthocyanin rich F1 fraction did not reproduce this response. WBE and the BPF restored the colonic mucus layer. Particularly, the polymeric PACs-rich F3 fraction increased the mucin-secreting goblet cells number. WBE caused a significant 2-fold higher proportion of Adlercreutzia equolifaciens whereas oligomeric PACs-rich F2 fraction increased by 2.5-fold the proportion of Akkermansia muciniphila. This study reveals the key role of WBE PACs in modulating the gut microbiota and restoring colonic epithelial mucus layer, providing a suitable ecological niche for mucosa-associated symbiotic bacteria, which may be crucial in triggering health effects of blueberry polyphenols.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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