Effect of Vitamin D and Magnesium Supplementation on Behavior Problems in Children with Attention-Deficit Hyperactivity Disorder
Hemamy M, Heidari-Beni M, Askari G, Karahmadi M, Maracy M
International journal of preventive medicine · 17 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2020-01-01 · Int J Prev Med · vol. 11 · issue 1 · p. 4
- Publisher
- Medknow
- Cited
- 28 citations · more than 87% of similar papers · 2.1× the field average
- References
- 53 works
- Access
- Open access (journal) · CC-BY-NC-SA
- Research areas
- Attention Deficit Hyperactivity Disorder · Bipolar Disorder and Treatment · Vitamin D Research Studies
- Keywords
- Medicine, Placebo, Impulsivity, Vitamin D and neurology, Anxiety, Attention deficit hyperactivity disorder, Randomized controlled trial, Vitamin, Magnesium, Pediatrics, Psychiatry, Internal medicine, Alternative medicine
5 authors
From IR
- Mostafa HemamyIsfahan University of Medical Sciences
- Motahar Heidari‐BeniIsfahan University of Medical Sciences
- Gholamreza Askari · correspondingIsfahan University of Medical Sciences
- Mojgan KarahmadiIsfahan University of Medical Sciences
- Mohammad Reza MaracyIsfahan University of Medical Sciences
Abstract
Background
Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by the three main symptom domains including inattention, hyperactivity, and impulsivity. Recent findings suggested that nutrients might play an important role in the pathology of ADHD. The present study aimed to examine the effects of Vitamin D and magnesium supplementation on behavior problems in children with ADHD.
Methods
This double-blind, randomized controlled clinical trial study was conducted on 66 children with ADHD in Clinic of Noor and Ali Asghar Hospital in Isfahan, Iran, in 2016. Children were randomly allocated to receive both Vitamin D (50,000 IU/week) and magnesium (6 mg/kg/day) supplements (n = 33) or placebos (n = 33) for 8 weeks. Conners' Parent Rating Scale was used to evaluate children's behavior at baseline and at the end of the study.
Results
After 8 weeks of Vitamin D consumption as well as magnesium, the serum levels of 25-hydroxy-Vitamin D3 and magnesium increased significantly in the intervention group compared with placebo group. Supplementation with Vitamin D and magnesium caused a significant decrease in conduct problems, social problems, and anxiety/shy scores; but it had no significant effect on psychosomatic problems score.
Conclusions
Vitamin D and magnesium supplementation in children with ADHD was effective on conduct problems, social problems, and anxiety/shy scores compared with placebo intake, but it did not affect psychosomatic problem scores, significantly.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
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