Effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammatory biomarkers, and SIRT1 in obese women: a study protocol for a double-blind, randomized, placebo-controlled trial
Abiri B, Vafa M
Trials · 21 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institute for Medical Research Development
- Government
- National Institute for Medical Research Development (NIMAD)
- Grants
- National Institute for Medical Research Development (982923)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-02-26 · Trials · vol. 21 · issue 1 · p. 225
- Publisher
- Springer Science+Business Media
- Cited
- 28 citations · more than 87% of similar papers · 2.2× the field average
- References
- 50 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Medicine, Randomized controlled trial, Internal medicine, Placebo, Vitamin D and neurology, Mood, Body mass index, Inflammation, Endocrinology, Gastroenterology, Physical therapy, Psychiatry, Pathology
- MeSH
- humans, obesity, inflammation, magnesium, brain-derived neurotrophic factor, vitamin d, c-reactive protein, double-blind method, affect, dietary supplements, adolescent, adult, middle aged, female, young adult, sirtuin 1, outcome assessment, health care
2 authors
From IR
- Behnaz AbiriAhvaz Jundishapur University of Medical Sciences
- Mohammadreza Vafa · correspondingIran University of Medical Sciences
Abstract
Background
Emerging evidence has shown that vitamin D and magnesium have anti-inflammatory and anti-depressant effects. Dietary intake of magnesium is associated with reduced body mass index, waist circumference, body fat percentage, as well as inflammatory biomarkers and depressive symptoms. Vitamin D deficiency has been linked to inflammation, obesity, and depressive symptoms. This study will test the effects of vitamin D and magnesium co-supplementation on mood, serum level of brain-derived neurotrophic factor (BDNF), inflammation, and sirtuin 1 (SIRT1) in obese women.
Methods
We will conduct an 8-week, double-blind, randomized, placebo-controlled clinical trial, in a factorial design, to evaluate the individual effects of vitamin D and magnesium, and co-supplementation of them, on mood, serum level of BDNF, inflammation, and SIRT1 in 108 obese women.
Discussion
We hypothesize that vitamin D and magnesium co-supplementation may provide a new adjuvant therapy through modulation of BDNF, inflammation, and SIRT1 in obese women.
Trial registration
Iranian Registry of Clinical Trials, IRCT20090822002365N23. Registered on 16 August 2019.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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