Magnesium intake and primary liver cancer incidence and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Zhong GC, Peng Y, Wang K, Wan L, Wu YQ, Hao FB, Hu JJ, Gu HT
International journal of cancer · 21 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-02-27 · Int J Cancer · vol. 147 · issue 6 · pp. 1577–1586
- Publisher
- Wiley
- Cited
- 24 citations · more than 82% of similar papers · 1.6× the field average
- References
- 59 works
- Access
- Free to read
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Nutritional Studies and Diet
- Keywords
- Medicine, Hazard ratio, Incidence (geometry), Confidence interval, Proportional hazards model, Population, Internal medicine, Cohort study, Surgery, Environmental health
- MeSH
- humans, liver neoplasms, magnesium deficiency, magnesium, diet surveys, incidence, risk factors, survival analysis, follow-up studies, prospective studies, feeding behavior, dietary supplements, aged, middle aged, female, male, multicenter studies as topic, randomized controlled trials as topic, early detection of cancer
8 authors
From CN
- Guo‐Chao Zhong · correspondingDalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Yang PengChengdu Fifth People's Hospital
- Kang WangThe Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
- Lun WanChongqing Dazu District People's Hospital
- You‐Qi‐Le WuChongqing Public Health Medical Center; Chongqing Medical University
- Fa‐Bao HaoQingdao University; Qingdao Women and Children's Hospital
Abstract
Epidemiological studies on magnesium intake and primary liver cancer (PLC) are scarce, and no prospective studies have examined the associations of magnesium intake with PLC incidence and mortality. We sought to clarify whether higher magnesium intake from diet and supplements was associated with lower risks of PLC incidence and mortality in the US population. Magnesium intake from diet and supplements was evaluated through a food frequency questionnaire in a cohort of 104,025 participants. Cox regression was employed to calculate hazard ratios for PLC incidence and competing risk regression was employed to calculate subdistribution hazard ratios for PLC mortality. Restricted cubic spline regression was employed to test nonlinearity. We documented 116 PLC cases during 1,193,513.5 person-years of follow-up and 100 PLC deaths during 1,198,021.3 person-years of follow-up. Total (diet + supplements) magnesium intake was found to be inversely associated with risks of PLC incidence (hazard ratiotertile 3 vs. 1 : 0.44; 95% confidence interval: 0.24, 0.80; ptrend = 0.0065) and mortality (subdistribution hazard ratiotertile 3 vs. 1 : 0.37; 95% confidence interval: 0.19, 0.71; ptrend = 0.0008). Similar results were obtained for dietary magnesium intake. Nonlinear inverse dose-response associations with PLC incidence and mortality were observed for both total and dietary magnesium intakes (all pnonlinearity < 0.05). In summary, in the US population, a high magnesium intake is associated with decreased risks of PLC incidence and mortality in a nonlinear dose-response manner. These findings support that increasing the consumption of foods rich in magnesium may be beneficial in reducing PLC incidence and mortality.
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