Serum 25-Hydroxyvitamin D and the risk of mortality in adult patients with Sepsis: a meta-analysis
Li Y, Ding S
BMC infectious diseases · 41 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2020-03-04 · BMC Infect Dis · vol. 20 · issue 1 · p. 189
- Publisher
- BioMed Central
- Cited
- 77 citations · more than 96% of similar papers · 3.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Adrenal Hormones and Disorders · Vitamin C and Antioxidants Research
- Keywords
- Medicine, Sepsis, Internal medicine, vitamin D deficiency, Relative risk, Vitamin D and neurology, Meta-analysis, Subgroup analysis, Systemic inflammatory response syndrome, Gastroenterology, Prospective cohort study, Lower risk, Risk of mortality, Confidence interval
- MeSH
- humans, sepsis, vitamin d deficiency, vitamin d, prognosis, incidence, risk, follow-up studies, adult, aged, middle aged, female, male
2 authors
From CN
- Yuye LiShandong University; Shandong Chest Hospital
- Shifang Ding · correspondingQilu Hospital of Shandong University
Abstract
Background
Vitamin D deficiency has been related to the risk of sepsis. However, previous studies showed inconsistent results regarding the association between serum 25-hydroxyvitamin D (25 (OH) D) and mortality risk in septic patients. We aimed to evaluate the relationship between serum 25 (OH) D at admission and mortality risk in adult patients in a meta-analysis.
Methods
Follow-up studies that provided data of multivariate adjusted relative risk (RR) between serum 25 (OH) D and mortality risk in septic patients were retrieved via systematic search of PubMed and Embase databases. A random effect model was used to pool the results.
Results
Eight studies with 1736 patients were included. Results of overall meta-analysis showed that lower 25 (OH) D at admission was independently associated with increased risk or mortality (adjusted RR: 1.93, p 2 = 63%) in patients with sepsis. Exploring subgroup association showed that patients with severe vitamin D deficiency (25 (OH) D < 10 ng/ml) was significantly associated with higher mortality risk (adjusted RR: 1.92, p < 0.001), but the associations were not significant for vitamin D insufficiency (25 (OH) D 20~30 ng/ml) or deficiency (25 (OH) D 10~20 ng/ml). Further analyses showed that the association between lower serum 25 (OH) D and higher mortality risk were consistent in studies applied different diagnostic criteria for sepsis (systemic inflammatory response syndrome, Sepsis-2.0, or Sepsis-3.0), short-term (within 1 month) and long-term studies (3~12 months), and in prospective and retrospective studies.
Conclusions
Severe vitamin D deficiency may be independently associated with increased mortality in adult patients with sepsis. Large-scale prospective studies are needed to validate our findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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