Associations of habitual fish oil supplementation with cardiovascular outcomes and all cause mortality: evidence from a large population based cohort study
Li ZH, Zhong WF, Liu S, Kraus VB, Zhang YJ, Gao X, Lv YB, Shen D, Zhang XR, Zhang PD, Huang QM, Chen Q, Wu XB, Shi XM, Wang D, Mao C
BMJ (Clinical research ed.) · 69 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- NIA NIH HHS
- Grants
- National Institute on Aging (P30/AG028716); National Natural Science Foundation of China (81973109); National Institutes of Health (P30-AG-028716); National Institutes of Health (AG028716)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-03-04 · BMJ · vol. 368 · p. m456
- Cited
- 102 citations · more than 98% of similar papers · 6.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 49 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Coenzyme Q10 studies and effects
- Keywords
- Medicine, Hazard ratio, Cohort, Fish oil, Prospective cohort study, Cohort study, Biobank, Confidence interval, Population, Demography, Internal medicine, Environmental health, Fish <Actinopterygii>, Biology, Bioinformatics
- MeSH
- humans, cardiovascular diseases, fish oils, risk factors, prospective studies, dietary supplements, adult, aged, middle aged, female, male, united kingdom
16 authors
From CN, US
- Zhihao LiSouthern Medical University
- Wen-Fang ZhongSouthern Medical University
- Simin LiuBrown University
- Virginia B. KrausDuke University
- Yu-Jie ZhangSouthern Medical University
- Xiang GaoPennsylvania State University
Abstract
Objectives
To evaluate the associations of habitual fish oil supplementation with cardiovascular disease (CVD) and mortality in a large prospective cohort.
Design
Population based, prospective cohort study.
Setting
UK Biobank.
Participants
A total of 427 678 men and women aged between 40 and 69 who had no CVD or cancer at baseline were enrolled between 2006 and 2010 and followed up to the end of 2018.
Main exposure
All participants answered questions on the habitual use of supplements, including fish oil.
Main outcome measures
All cause mortality, CVD mortality, and CVD events.
Results
At baseline, 133 438 (31.2%) of the 427 678 participants reported habitual use of fish oil supplements. The multivariable adjusted hazard ratios for habitual users of fish oil versus non-users were 0.87 (95% confidence interval 0.83 to 0.90) for all cause mortality, 0.84 (0.78 to 0.91) for CVD mortality, and 0.93 (0.90 to 0.96) for incident CVD events. For CVD events, the association seemed to be stronger among those with prevalent hypertension (P for interaction=0.005).
Conclusions
Habitual use of fish oil seems to be associated with a lower risk of all cause and CVD mortality and to provide a marginal benefit against CVD events among the general population.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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