Gender Differences in the Response to Short-term Cold Exposure in Young Adults
Mengel LA, Seidl H, Brandl B, Skurk T, Holzapfel C, Stecher L, Claussnitzer M, Hauner H
The Journal of clinical endocrinology and metabolism · 25 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Possibly industry funded
- Unclassified
- Bad Homburg.
- Company
- Else Kröner-Fresenius Stiftung, Bad Homburg
- University or hospital
- ZIEL-Institute for Food and Health
Based on 3 listed funder(s).
Publication
- Published
- 2020-03-07 · J Clin Endocrinol Metab · vol. 105 · issue 5 · pp. e1938–e1948
- Publisher
- Oxford University Press
- Cited
- 33 citations · more than 86% of similar papers · 1.9× the field average
- References
- 71 works
- Access
- Free to read
- Research areas
- Adipose Tissue and Metabolism · Thermoregulation and physiological responses · Exercise and Physiological Responses
- Keywords
- Thermogenesis, Internal medicine, Endocrinology, Context (archaeology), Basal metabolic rate, Adiponectin, Medicine, Resting energy expenditure, Body mass index, Leptin, Brown adipose tissue, Hormone, Energy metabolism, Young adult, Adipose tissue, Obesity, Biology, Insulin resistance
- MeSH
- humans, leptin, blood glucose, basal metabolism, cross-sectional studies, adaptation, physiological, body composition, energy metabolism, thermogenesis, sex characteristics, adult, female, male, adiponectin, adipose tissue, brown, cold temperature, young adult
8 authors
From DE, US
- Laura Aline MengelTechnical University of Munich
- Hatti SeidlTechnical University of Munich
- Beate BrandlTechnical University of Munich
- Thomas SkurkTechnical University of Munich
- Christina M. HolzapfelTechnical University of Munich
- Lynne StecherTechnical University of Munich
Abstract
Context
Cold exposure (CE) has been shown to enhance energy expenditure by activating brown adipose tissue thermogenesis and metabolism in humans. However, it remains to be elucidated if there are gender-specific differences in cold-induced thermogenesis and metabolism.
Objective
To study the impact of mild CE on resting energy expenditure (REE) and metabolism in males compared with females.
Setting
A cross-sectional study.
Participants
117 healthy young Caucasians participated in this study (58 males). Mean age was 25.1 ± 3.6 years and mean body mass index 22.3 ± 1.7 kg/m2.
Intervention
Participants underwent a short-term CE using water perfused mattresses to activate nonshivering thermogenesis.
Main outcome measures
REE was assessed before and 2 hours after CE followed by blood sampling. Selected metabolites and hormones were measured. Skin temperatures were monitored at various sites throughout the experiment.
Results
Participants showed a significant increase in REE after CE (6.5%, P < .001). This increase did not differ between genders (P = .908). However, there were differences between males and females in changes of plasma glucose (-5.1% versus -7.4%, P = .024), leptin (-14.3% versus -30.1%, P < .001) and adiponectin (5.4% versus 12.8%, P = .018) after CE. We observed a significant decrease of the supraclavicular skin temperature in men (-0.3%, P = .034), but not in women (0.3%, P = .326)(P = .019 between genders).
Conclusions
We did not observe a difference in the thermogenic response, measured as change of REE, to CE in women compared with men. However, we found that some metabolic and hormonal changes were more pronounced in women than in men suggesting a gender-specific response to cold.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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