Effect of 4 weeks daily wild blueberry supplementation on symptoms of depression in adolescents
Fisk J, Khalid S, Reynolds SA, Williams CM
The British journal of nutrition · 31 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Cancer Research UK
- Government
- Medical Research Council
- Grants
- Medical Research Council (C864/A8257); Cancer Research UK (G9502233); Cancer Research UK (C865/A2883); Cancer Research UK (G0401527); Medical Research Council (G9502233); Cancer Research UK (G1000143); Medical Research Council (C864/A14136); Cancer Research UK (SP2024/0201); Cancer Research UK (C864/A14136); Cancer Research UK (A8257); Medical Research Council (G0401527); Cancer Research UK (A14136); Medical Research Council (G1000143); Cancer Research UK (SP2024–0204); Cancer Research UK (C/864/A8257)
Based on 2 listed funder(s).
Publication
- Published
- 2020-03-10 · Br J Nutr · vol. 124 · issue 2 · pp. 181–188
- Publisher
- Cambridge University Press
- Cited
- 45 citations · more than 94% of similar papers · 4.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Free to read
- Research areas
- Medicinal Plant Extracts Effects · Phytochemicals and Antioxidant Activities · Olfactory and Sensory Function Studies
- Keywords
- Anxiety, Mood, Placebo, Depression (economics), Affect (linguistics), Medicine, Randomized controlled trial, Young adult, Intervention (counseling), Internal medicine, Psychiatry, Psychology
4 authors
From GB
- Jeni FiskUniversity of Reading
- Sundus Khalid · correspondingUniversity of Reading
- Shirley A. ReynoldsUniversity of Reading
- Claire Michelle Williams · correspondingUniversity of Reading
Abstract
Adolescence is an important period for cognitive maturation and emotional regulation, and this age group is particularly vulnerable to developing depression. Diets rich in fruits and vegetables have been associated with decreased risk of developing depressive disorders across the lifespan, maybe due to the high flavonoid content of these foods. Previously, we have shown increases in transient positive affect (PA) in both children and young adults 2 h after administration of a wild blueberry (WBB) intervention. Here, using a randomised double-blind, placebo-controlled trial, we investigated the effects of 4 weeks, daily WBB supplementation (containing about 253 mg anthocyanins) on transient and chronic mood in adolescents. Healthy 12-17-year old (n 64, thirty-five females) participants were randomly assigned to receive either a WBB or matched placebo supplementation. Depression and anxiety symptoms were assessed before and after the intervention period using the Mood and Feeling Questionnaire and Revised Child Anxiety and Depression Scale. Transient affect was assessed before, 2 weeks and at 4 weeks using PA and negative affect. Following the intervention period, there were significantly fewer self-reported depression symptoms in participants who were supplemented with WBB compared with placebo (P = 0·02, 95 % CI -6·71, -5·35). There was no between-group effect on anxiety symptoms or on transient affect. Further investigation is required to identify specific mechanisms that link flavonoids consumption and mood. If replicated, the observed effects of WBB supplementation may be a potential prevention strategy for adolescent depression and may have benefits for public mental health.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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