Transcranial Photobiomodulation (tPBM) With 1,064-nm Laser to Improve Cerebral Metabolism of the Human Brain In Vivo
Pruitt T, Wang X, Wu A, Kallioniemi E, Husain MM, Liu H
Lasers in surgery and medicine · 65 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Institute of Mental Health
- Government
- NIMH NIH HHS
- Grants
- National Institute of Mental Health (RF1 MH114285); National Institutes of Health (1rf1mh114285-01)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-03-15 · Lasers Surg Med · vol. 52 · issue 9 · pp. 807–813
- Publisher
- Wiley
- Cited
- 84 citations · more than 96% of similar papers · 4.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Laser Applications in Dentistry and Medicine · Dermatologic Treatments and Research · Photodynamic Therapy Research Studies
- Keywords
- Medicine, Transcranial magnetic stimulation, Human brain, Statistical significance, In vivo, Audiology, Stimulation, Psychology, Anesthesia, Internal medicine, Psychiatry, Biology
- MeSH
- brain, humans, spectroscopy, near-infrared, reproducibility of results, lasers, aged, child, preschool, hemodynamics
6 authors
From US
- Tyrell PruittThe University of Texas at Arlington; Southwestern Medical Center; Southwestern Medical Center; The University of Texas Southwestern Medical Center
- Xinlong WangThe University of Texas at Arlington
- Anqi WuThe University of Texas at Arlington
- Elisa KallioniemiSouthwestern Medical Center; Southwestern Medical Center; The University of Texas Southwestern Medical Center
- Mustafa M. HusainSouthwestern Medical Center; Southwestern Medical Center; The University of Texas Southwestern Medical Center
- Hanli Liu · correspondingThe University of Texas at Arlington
Abstract
Background and objectives
In our previous proof-of-principle study, transcranial photobiomodulation (tPBM) with 1,064-nm laser was reported to significantly increase concentration changes of oxygenated hemoglobin (∆[HbO]) and oxidized-state cytochrome c oxidase (∆[oxi-CCO]) in the human brain. This paper further investigated (i) its validity in two different subsets of young human subjects at two study sites over a period of 3 years and (ii) age-related effects of tPBM by comparing sham-controlled increases of ∆[HbO] and ∆[oxi-CCO] between young and older adults.
Study design/materials and methods
We measured sham-controlled ∆[HbO] and ∆[oxi-CCO] using broadband near-infrared spectroscopy (bb-NIRS) in 15 young (26.7 ± 2.7 years of age) and 5 older (68.2 ± 4.8 years of age) healthy normal subjects before, during, and after right-forehead tPBM/sham stimulation with 1,064-nm laser. Student t tests were used to test statistical differences in tPBM-induced ∆[HbO] and ∆[oxi-CCO] (i) between the 15 young subjects and those of 11 reported previously and (ii) between the two age groups measured in this study.
Results
Statistical analysis showed that no significant difference existed in ∆[HbO] and ∆[oxi-CCO] during and post tPBM between the two subsets of young subjects at two study sites over a period of 3 years. Furthermore, the two age groups showed statistically identical net increases in sham-controlled ∆[HbO] and ∆[oxi-CCO].
Conclusions
This study provided strong evidence to validate/confirm our previous findings that tPBM with 1,064-nm laser enables to increase cerebral ∆[HbO] and ∆[oxi-CCO] in the human brain, as measured by bb-NIRS. Overall, it demonstrated the robust reproducibility of tPBM being able to improve cerebral hemodynamics and metabolism of the human brain in vivo in both young and older adults. Lasers Surg. Med. © 2020 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals, Inc.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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