Relationship Between Dietary Magnesium Intake and Incident Heart Failure Among Older Women: The WHI
Wu WC, Huang M, Taveira TH, Roberts MB, Martin LW, Wellenius GA, Johnson KC, Manson JE, Liu S, Eaton CB
Journal of the American Heart Association · 14 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Heart, Lung, and Blood Institute
- Government
- NHLBI NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (HHSN268201600018C); National Heart, Lung, and Blood Institute (HHSN268201600004C); National Heart, Lung, and Blood Institute (HHSN268201600001C); National Heart, Lung, and Blood Institute (HHSN268201600003C); National Heart, Lung, and Blood Institute (HHSN268201600002C)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-03-20 · J Am Heart Assoc · vol. 9 · issue 7 · p. e013570
- Publisher
- Wiley
- Cited
- 16 citations · more than 73% of similar papers · 1.0× the field average
- References
- 41 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Keywords
- Medicine, Women's Health Initiative, Quartile, Hazard ratio, Proportional hazards model, Confounding, Heart failure, Internal medicine, Cohort study, Cohort, Observational study, Confidence interval
- MeSH
- humans, magnesium deficiency, magnesium, diet, incidence, risk assessment, prospective studies, age factors, postmenopause, ventricular function, left, time factors, dietary supplements, aged, middle aged, united states, female, heart failure, recommended dietary allowances, heart disease risk factors
10 authors
From US
- Wen‐Chih Wu · correspondingBrown University; Miriam Hospital; Providence VA Medical Center
- Mengna HuangBrigham and Women's Hospital
- Tracey H. TaveiraUniversity of Rhode Island; Brown University; Miriam Hospital; Rhode Island College
- Mary B. RobertsMemorial Hospital of Rhode Island
- Lisa Warsinger MartinGeorge Washington University
- Gregory A. WelleniusBrown University
Abstract
Background Women represent a large proportion of the growing heart failure (HF) epidemic, yet data are lacking regarding optimal dietary and lifestyle prevention strategies for them. Specifically, the association between magnesium intake and HF in a multiracial cohort of women is uncertain. Methods and Results We included 97 725 postmenopausal women from the WHI (Women's Health Initiative) observational studies and placebo arms of the hormone trial. Magnesium intake was measured at baseline by a 122-item validated food-frequency questionnaire and stratified into quartiles based on diet only, total intake (diet with supplements), and residual intake (calibration by total energy). Incident hospitalized HF (2153 events, median follow-up 8.1 years) was adjudicated by medical record abstraction. In Cox proportional hazards models, we evaluated the association between magnesium intake and HF adjusting for potential confounders. Analyses were repeated on a subcohort (n=18 745; median-follow-up, 13.2 years) for whom HF cases were subclassified into preserved ejection fraction (526 events), reduced ejection fraction (291 events) or unknown (168 events). Most women were white (85%) with a mean age of 63. Compared with the highest quartile of magnesium intake, women in the lowest quartile had an increased risk of incident HF, with adjusted hazard ratios of 1.32 (95% CI, 1.02-1.71) for diet only (P trend=0.03), 1.26 (95% CI, 1.03-1.56) for total intake, and 1.31 (95% CI, 1.02-1.67) for residual intake. Results did not significantly vary by race. Subcohort analyses showed low residual magnesium intake was associated with HF with reduced ejection fraction (hazard ratio, 1.81, lowest versus highest quartile; 95% CI, 1.08-3.05) but not HF with preserved ejection fraction. Conclusions Low magnesium intake in a multiracial cohort of postmenopausal women was associated with a higher risk of incident HF, especially HF with reduced ejection fraction.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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