Association of magnesium intake with type 2 diabetes and total stroke: an updated systematic review and meta-analysis
Zhao B, Zeng L, Zhao J, Wu Q, Dong Y, Zou F, Gan L, Wei Y, Zhang W
BMJ open · 41 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Natural Science Foundation of Jiangxi Province
- University or hospital
- Nanchang University
- Grants
- National Natural Science Foundation of China (81560345); Natural Science Foundation of Jiangxi Province (20161BAB215237)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-03-01 · BMJ Open · vol. 10 · issue 3 · p. e032240
- Publisher
- BMJ
- Cited
- 82 citations · more than 93% of similar papers · 2.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 81 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Keywords
- Medicine, Relative risk, Meta-analysis, Stroke (engine), Cochrane Library, Internal medicine, Type 2 diabetes, Subgroup analysis, Prospective cohort study, Diabetes mellitus, Cohort study, Confidence interval, Endocrinology
- MeSH
- humans, brain ischemia, diabetes mellitus, type 2, magnesium, prospective studies, female, male, stroke
9 authors
From CN
- Binghao ZhaoNanchang University; Second Affiliated Hospital of Nanchang University
- Lianli ZengNanchang University; Second Affiliated Hospital of Nanchang University
- Jiani ZhaoNanchang University; Second Affiliated Hospital of Nanchang University
- Qian WuNanchang University; Second Affiliated Hospital of Nanchang University
- Yifei DongNanchang University; Second Affiliated Hospital of Nanchang University
- Fang ZouNanchang University; Second Affiliated Hospital of Nanchang University
Abstract
Objective
The detailed associations between type 2 diabetes (T2D) and total stroke and magnesium intake as well as the dose-response trend should be updated in a timely manner.
Design
Systematic review and meta-analyses.
Data sources
PubMed, Embase, Cochrane Library, Web of Science and ClinicalTrials.gov were rigorously searched from inception to 15 March 2019.
Eligibility criteria
Prospective cohort studies investigating these two diseases were included.
Data synthesis
Relative risk (RR) and 95% CI in random effects models as well as absolute risk (AR) were pooled to calculate the risk of T2D and stroke. Methodological quality was assessed by the Newcastle-Ottawa Scale.
Results
Forty-one studies involving 53 cohorts were included. The magnitude of the risk was significantly reduced by 22% for T2D (RR 0.78 (95% CI 0.75 to 0.81); p2 body mass index and those with ≥12-year follow-up; the reduced risk in Asians was not as notable as that in North American and European populations.
Conclusions
Magnesium intake has significantly inverse associations with T2D and total stroke in a dose-dependent manner. Feasible magnesium-rich dietary patterns may be highly beneficial for specific populations and could be highlighted in the primary T2D and total stroke prevention strategies disseminated to the public.
Prospero registration number
CRD42018092690.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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