Effects of whole body cryotherapy in patients with rheumatoid arthritis considering immune parameters
Sadura-Sieklucka T, Sołtysiuk B, Karlicka A, Sokołowska B, Kontny E, Księżopolska-Orłowska K
Reumatologia · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-12-31 · Reumatologia · vol. 57 · issue 6 · pp. 320–325
- Publisher
- Termedia Publishing House
- Cited
- 29 citations · more than 83% of similar papers · 1.6× the field average
- References
- 18 works
- Access
- Open access (free to publish) · CC-BY-NC-SA
- Research areas
- Exercise and Physiological Responses · Therapeutic Uses of Natural Elements · Rheumatoid Arthritis Research and Therapies
- Keywords
- Medicine, Rheumatoid arthritis, Erythrocyte sedimentation rate, Visual analogue scale, Immune system, Rehabilitation, Internal medicine, Cryotherapy, Tumor necrosis factor alpha, Arthritis, Rheumatoid factor, Morning, Gastroenterology, Immunology, Physical therapy, Surgery
6 authors
From PL
- Teresa Sadura-SiekluckaNational Institute of Geriatrics, Rheumatology and Rehabilitation
- Beata SołtysiukNational Institute of Geriatrics, Rheumatology and Rehabilitation
- Anna KarlickaNational Institute of Geriatrics, Rheumatology and Rehabilitation
- Beata SokołowskaMossakowski Medical Research Institute, Polish Academy of Sciences; Polish Academy of Sciences
- Ewa KontnyNational Institute of Geriatrics, Rheumatology and Rehabilitation
- Krystyna Księżopolska-OrłowskaNational Institute of Geriatrics, Rheumatology and Rehabilitation
Abstract
Objectives
Whole body cryotherapy (WBC) is widely used in inflammatory diseases of the joints, including rheumatoid arthritis (RA), but the mechanism(s) of its action is not fully understood. The aim of the study was to compare the effects of WBC and conventional rehabilitation (CR) on the clinical and immune status of RA patients.
Material and methods
Rheumatoid arthritis patients were classified into 2 groups according to the rehabilitation method used: the study group (CT, n = 25) and control group (CR, n = 25). To measure disease activity, the disease activity score (DAS28) was used, while to assess the morning stiffness and pain intensity, the visual analogue scale (VAS) was applied. Selected laboratory parameters, such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, were also determined. The serum concentrations of pro- (interleukin 6 [IL-6], tumor necrosis factor α [TNF-α], macrophage migration inhibitory factor [MIF]) and anti-inflammatory (IL-10) cytokines were measured to assess the patient's immune status.
Results
After rehabilitation disease activity (DAS28), morning stiffness and pain intensity (VAS) decreased in both patient groups and no statistically significant differences were observed between them. However, statistically significant improvement in the CRP serum level was observed in the CT group only. No differences were observed in the serum concentrations of tested cytokines either before and after rehabilitation, or between patient groups.
Conclusions
We report that regardless of the type of therapy, comprehensive rehabilitation improves the patient's clinical status, but has no effect on the levels of circulating cytokines, such as IL-6, IL-10, TNF-α, and MIF, despite significant reduction of a systemic inflammatory marker (CRP), especially in the CT group.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.