Effect of time restricted feeding on the gut microbiome in adults with obesity: A pilot study
Gabel K, Marcell J, Cares K, Kalam F, Cienfuegos S, Ezpeleta M, Varady KA
Nutrition and health · 80 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Illinois Chicago Campus Research Board Grant
Based on 1 listed funder(s).
Publication
- Published
- 2020-03-30 · Nutr Health · vol. 26 · issue 2 · pp. 79–85
- Publisher
- SAGE Publishing
- Cited
- 97 citations · more than 97% of similar papers · 5.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 23 works
- Access
- Paywalled
- Research areas
- Dietary Effects on Health · Gut microbiota and health · Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Bacteroidetes, Firmicutes, Microbiome, Gut flora, Biology, Feces, Obesity, Phylogenetic diversity, Gut microbiome, Physiology, Metagenomics, Zoology, Microbiology, 16S ribosomal RNA, Endocrinology, Bioinformatics, Phylogenetic tree, Genetics, Immunology, Bacteria, Gene
- MeSH
- feces, humans, bacteroidetes, obesity, body weight, weight loss, rna, bacterial, rna, ribosomal, 16s, fasting, pilot projects, feeding behavior, phylogeny, time factors, adult, aged, middle aged, gastrointestinal microbiome, bacillota
7 authors
From US
- Kelsey Gabel · correspondingUniversity of Illinois Chicago
- Jarrad MarcellUniversity of Illinois Chicago
- Kate CaresUniversity of Illinois Chicago
- Faiza KalamUniversity of Illinois Chicago
- Sofia CienfuegosUniversity of Illinois Chicago
- Mark EzpeletaUniversity of Illinois Chicago
Abstract
Background
Time restricted feeding is a form of intermittent fasting where participants shorten the daily window in which they eat.
Aim
This is the first study to examine the effects of intermittent fasting on changes in the gut microbiome.
Methods
Adults with obesity (n = 14) participated in a daily 8-hour time restricted feeding intervention (8-hour feeding window/16-hour fasting window) for 12 weeks. Fecal microbiota were determined by 16 S rRNA (ribosomal ribonucleic acid) gene sequencing of stool samples.
Results
Body weight decreased (P < 0.05) by -2 ± 1 kg. Gut microbiota phylogenetic diversity remained unchanged. The two most common phyla were Firmicutes and Bacteroidetes accounting for 61.2% and 26.9% of total abundance at baseline. No significant alterations in the abundance of Firmicutes, Bacteroidetes, or any other phyla were detected after 12 weeks of time restricted feeding.
Conclusions
Time restricted feeding did not significantly alter the diversity or overall composition of the gut microbiome.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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