Changes in Nut Consumption and Subsequent Cardiovascular Disease Risk Among US Men and Women: 3 Large Prospective Cohort Studies
Liu X, Guasch-Ferré M, Drouin-Chartier JP, Tobias DK, Bhupathiraju SN, Rexrode KM, Willett WC, Sun Q, Li Y
Journal of the American Heart Association · 25 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Government
- NCI NIH HHS
- Government
- NHLBI NIH HHS
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Cancer Institute (U01 CA167552); National Heart, Lung, and Blood Institute (U01 HL145386); National Heart, Lung, and Blood Institute (R01-HL034594); National Cancer Institute (UM1 CA186107); National Heart, Lung, and Blood Institute (R01 HL035464); National Heart, Lung, and Blood Institute (R01-HL-088521); National Cancer Institute (U01 CA176726); National Cancer Institute (UM1-CA-167552); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK120870); National Cancer Institute (UM1 CA176726)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-04-01 · J Am Heart Assoc · vol. 9 · issue 7 · p. e013877
- Publisher
- Wiley
- Cited
- 39 citations · more than 92% of similar papers · 3.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Nuts composition and effects · Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress
- Keywords
- Medicine, Relative risk, Confidence interval, Prospective cohort study, Lower risk, Proportional hazards model, Stroke (engine), Cohort study, Internal medicine, Nut, Nurses' Health Study
- MeSH
- humans, nuts, cardiovascular diseases, prognosis, incidence, risk assessment, prospective studies, feeding behavior, risk reduction behavior, sex factors, primary prevention, nutritive value, time factors, adult, aged, middle aged, united states, female, male, protective factors, diet, healthy, heart disease risk factors
9 authors
From US
- Xiaoran LiuHarvard University
- Marta Liu Guasch-FerréBrigham and Women's Hospital; Harvard University
- Jean‐Philippe Drouin‐ChartierHarvard University
- Deirdre Kay TobiasBrigham and Women's Hospital; Harvard University
- Shilpa N BhupathirajuBrigham and Women's Hospital; Harvard University
- Kathryn M. RexrodeBrigham and Women's Hospital; Harvard University
Abstract
Background We aim to evaluate the association of within-individual changes in consumption of total and specific types of nuts and the subsequent risk of incident cardiovascular disease (CVD) in US men and women. Methods and Results We included 34 103 men from the HPFS (Health Professionals Follow-Up Study) (1986-2012), 77 815 women from the NHS (Nurses' Health Study) (1986-2012), and 80 737 women from the NHS II (1991-2013). We assessed nut consumption every 4 years using validated food frequency questionnaires. We used multivariable Cox proportional hazards regression models to examine the association between 4-year changes in nut consumption and risk of confirmed CVD end points in the subsequent 4 years. Per 0.5 serving/day increase in total nut consumption was associated with lower risk of CVD (relative risk [RR], 0.92; 95% CI, 0.86-0.98), coronary heart disease (RR, 0.94; 95% CI, 0.89-0.99), and stroke (RR, 0.89; 95% CI, 0.83-0.95). Compared with individuals who remained nonconsumers in a 4-year interval, those who had higher consumption of total nuts (≥0.5 servings/day) had a lower risk of CVD (RR, 0.75; 95% CI, 0.67-0.84), coronary heart disease (RR, 0.80; 95% CI, 0.69-0.93), and stroke (RR, 0.68; 95% CI, 0.57-0.82) in next 4 years. Individuals who decreased nut consumption by ≥0.50 servings/day had a higher risk of developing CVD (RR, 1.14; 95% CI, 0.99-1.32), coronary heart disease (RR, 1.06; 95% CI, 0.88-1.28), and stroke (RR, 1.28; 95% CI, 1.02-1.60) when compared with those who maintained their nut consumption. Conclusions Increasing total consumption of nuts and intake of individual types of nuts (eg, walnuts, other tree nuts, and peanuts) was associated with a subsequent lower risk of CVD. These data support the role of nut intake in the primary prevention of CVD. Registration URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00005152 and NCT00005182.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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