Associations between calcium and magnesium intake and the risk of incident oesophageal cancer: an analysis of the NIH-AARP Diet and Health Study prospective cohort
Shah SC, Dai Q, Zhu X, Peek RM, Roumie C, Shrubsole MJ
British journal of cancer · 16 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Veterans Affairs
- Government
- Agency for Healthcare Research and Quality
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- CSRD VA
- Government
- NIDDK NIH HHS
- Government
- AHRQ HHS
- Grants
- Agency for Healthcare Research and Quality (K12 HS026395); U.S. Department of Veterans Affairs (IK2 CX002027); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-058404)
Based on 6 listed funder(s).
Publication
- Published
- 2020-04-02 · Br J Cancer · vol. 122 · issue 12 · pp. 1857–1864
- Publisher
- Springer Nature
- Cited
- 24 citations · more than 88% of similar papers · 2.2× the field average
- References
- 31 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Esophageal Cancer Research and Treatment · Magnesium in Health and Disease · Parathyroid Disorders and Treatments
- Keywords
- Medicine, Prospective cohort study, Hazard ratio, Cohort study, Proportional hazards model, Internal medicine, Cancer, Cohort, Retrospective cohort study, Quartile, Lower risk, Confidence interval
- MeSH
- humans, esophageal neoplasms, calcium, dietary, magnesium, diet, diet surveys, incidence, risk factors, retrospective studies, aged, middle aged, female, male
6 authors
From US
- Shailja C. Shah · correspondingVA Tennessee Valley Healthcare System; Vanderbilt University Medical Center
- Qi DaiVanderbilt University Medical Center
- Xiangzhu ZhuVanderbilt University Medical Center
- Richard M. PeekVanderbilt University Medical Center
- Christianne L. RoumieVA Tennessee Valley Healthcare System; Vanderbilt University Medical Center
- Martha J. ShrubsoleVanderbilt University Medical Center
Abstract
Background
Risk reduction through dietary modifications is an adjunct strategy for prevention of oesophageal cancer, a leading cause of cancer-related mortality and morbidity worldwide. We aimed to estimate the association between calcium and magnesium intakes and incident oesophageal cancer (OC).
Methods
We conducted a retrospective analysis of the NIH-AARP Diet and Health Study prospective cohort. We used multivariable Cox proportional hazard modeling to estimate the association between total intakes and incident OC overall and by histology (oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC)). Sensitivity and stratified analyses were performed.
Results
Among 536,359 included respondents, 1414 incident OCs occurred over 6.5 million person-years follow-up time. Increasing dietary calcium intake was associated with an adjusted 32-41% lower risk of OSCC compared to the lowest quartile (p-trend 0.01). There was a positive association between increasing magnesium intake and OAC risk, but only among participants with low calcium:magnesium intake ratios (p-trend 0.04). There was a significant interaction with smoking status.
Conclusions
Based on a retrospective analysis of the NIH-AARP Diet and Health Study prospective cohort, dietary intakes of calcium and magnesium were significantly associated with risk of OSCC and, among certain participants, OAC, respectively. If validated, these findings could inform dietary modifications among at-risk individuals. Mechanistic investigations would provide additional insight.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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