Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
Revez JA, Lin T, Qiao Z, Xue A, Holtz Y, Zhu Z, Zeng J, Wang H, Sidorenko J, Kemper KE, Vinkhuyzen AAE, Frater J, Eyles D, Burne THJ, Mitchell B, Martin NG, Zhu G, Visscher PM, Yang J, Wray NR, McGrath JJ
Nature communications · 338 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Queensland Health
- University or hospital
- QIMR Berghofer Medical Research Institute
- Government
- National Research Foundation
- Government
- Danmarks Grundforskningsfond
- University or hospital
- Queensland University of Technology
- Government
- National Institutes of Health
- Government
- Medical Research Council
- Government
- Australian Research Council
- Government
- National Health and Medical Research Council
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Institute of Mental Health
- Government
- National Institute on Drug Abuse
- Government
- National Human Genome Research Institute
- Government
- NIH Office of the Director
- Government
- National Cancer Institute
- Government
- National Institute of Neurological Disorders and Stroke
- Government
- Common Fund
- Grants
- Queensland University of Technology (1113400); Medical Research Council (1113400); National Health and Medical Research Council (1124721); National Health and Medical Research Council (1007677); National Health and Medical Research Council (1113400); National Health and Medical Research Council (1078901); National Institutes of Health (12505); Medical Research Council (1078037); National Health and Medical Research Council (1124724); Queensland University of Technology (1078901); Australian Research Council (1113400); National Health and Medical Research Council (1056929); Medical Research Council (1078901); Australian Research Council (FT180100186); National Health and Medical Research Council (1078037); National Health and Medical Research Council (1099709); National Health and Medical Research Council (1141699)
Based on 17 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-04-02 · Nat Commun · vol. 11 · issue 1 · p. 1647
- Publisher
- Nature Portfolio
- Cited
- 461 citations · more than 100% of similar papers · 28.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 91 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Genetic Associations and Epidemiology · Digestive system and related health
- Keywords
- Genome-wide association study, Biology, Genome, Computational biology, Genetics, Association (psychology), Gene, Single-nucleotide polymorphism, Genotype, Psychology
- MeSH
- humans, vitamin d deficiency, vitamin d, polymorphism, single nucleotide, adult, aged, middle aged, female, male, genome-wide association study, mendelian randomization analysis, united kingdom, white people
21 authors
From AU, CN, DK
- Joana RevezThe University of Queensland; Institute for Molecular Bioscience
- Tian LinThe University of Queensland; Institute for Molecular Bioscience
- Zhen Guo QiaoThe University of Queensland; Institute for Molecular Bioscience
- Angli XueThe University of Queensland; Institute for Molecular Bioscience
- Yan HoltzThe University of Queensland
- Zhihong ZhuThe University of Queensland; Institute for Molecular Bioscience
Abstract
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this study.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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