Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study
Chow LS, Manoogian ENC, Alvear A, Fleischer JG, Thor H, Dietsche K, Wang Q, Hodges JS, Esch N, Malaeb S, Harindhanavudhi T, Nair KS, Panda S, Mashek DG
Obesity (Silver Spring, Md.) · 298 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- National Center for Advancing Translational Sciences
- Government
- NCATS NIH HHS
- Unclassified
- Healthy Foods Healthy Lives
- Government
- NCI NIH HHS
- Grants
- National Center for Advancing Translational Sciences ((UL1-TR002494)); National Cancer Institute (P30 CA-014195)
Based on 5 listed funder(s).
Publication
- Published
- 2020-04-09 · Obesity (Silver Spring) · vol. 28 · issue 5 · pp. 860–869
- Publisher
- Wiley
- Cited
- 363 citations · more than 100% of similar papers · 22.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Open access (repository copy)
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Enhanced Recovery After Surgery
- Keywords
- Overweight, Medicine, Weight loss, Lean body mass, Obesity, Randomized controlled trial, Body mass index, Anthropometry, Internal medicine, Animal science, Endocrinology, Body weight, Physical therapy, Biology
- MeSH
- humans, obesity, feasibility studies, body composition, adolescent, adult, aged, middle aged, female, male, overweight, young adult
14 authors
From US
- Lisa Senye Chow · correspondingUniversity of Minnesota
- Emily N. C. ManoogianSalk Institute for Biological Studies
- ALISON C. ALVEARUniversity of Minnesota
- Jason G. FleischerSalk Institute for Biological Studies
- Honoree ThorUniversity of Minnesota
- KATRINA B. DIETSCHEUniversity of Minnesota
Abstract
Objective
In contrast to intentionally restricting energy intake, restricting the eating window may be an option for treating obesity. By comparing time-restricted eating (TRE) with an unrestricted (non-TRE) control, it was hypothesized that TRE facilitates weight loss, alters body composition, and improves metabolic measures.
Methods
Participants (17 women and 3 men; mean [SD]: 45.5 [12.1] years; BMI 34.1 [7.5] kg/m2 ) with a prolonged eating window (15.4 [0.9] hours) were randomized to TRE (n = 11: 8-hour window, unrestricted eating within window) versus non-TRE (n = 9: unrestricted eating) for 12 weeks. Weight, body composition (dual x-ray absorptiometry), lipids, blood pressure, 2-hour oral glucose tolerance, 2-week continuous glucose monitoring, and 2-week physical activity (actigraphy assessed) were measured during the pre- and end-intervention periods.
Results
The TRE group significantly reduced the eating window (end-intervention window: 9.9 [2.0] hours) compared with the non-TRE group (end-intervention window: 15.1 [1.1] hours) (P < 0.01). Compared with non-TRE, TRE decreased the number of eating occasions, weight, lean mass, and visceral fat (all P ≤ 0.05). Compared with preintervention measures, the TRE group reduced the number of eating occasions (-21.9% [30.1%]) and reduced weight (-3.7% [1.8%]), fat mass (-4% [2.9%]), lean mass (-3.0% [2.7%]), and visceral fat (-11.1% [13.4%]) (all P ≤ 0.05). Physical activity and metabolic measures remained unchanged.
Conclusions
In the setting of a randomized trial, TRE presents a simplified view of food intake that reduces weight.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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