CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance
Grgic J, Pickering C, Bishop DJ, Schoenfeld BJ, Mikulic P, Pedisic Z
Journal of the International Society of Sports Nutrition · 43 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Authors
- At least one author declares a financial tie to industry
Based on full-text disclosure statement.
Publication
- Published
- 2020-01-03 · J Int Soc Sports Nutr · vol. 17 · issue 1 · p. 21
- Publisher
- Springer Science+Business Media
- Cited
- 58 citations · more than 96% of similar papers · 4.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Coffee research and impacts · Muscle metabolism and nutrition · Genetics and Physical Performance
- Keywords
- Bench press, Caffeine, Medicine, Wingate test, Jumping, Sprint, Ingestion, Placebo, Animal science, Internal medicine, Resistance training, Physical therapy, Anaerobic exercise, Physiology, Biology
- MeSH
- humans, caffeine, cytochrome p-450 cyp1a2, cross-over studies, double-blind method, genotype, adult, male, athletic performance, resistance training, young adult, performance-enhancing substances, sports nutritional physiological phenomena
6 authors
From AU, GB, US, HR
- Jozo Grgić · correspondingVictoria University
- Craig PickeringUniversity of Lancashire
- David John BishopEdith Cowan University; Victoria University
- Brad Jon SchoenfeldLehman College
- Pavle MikulićUniversity of Zagreb
- Željko PedišićVictoria University
Abstract
Background
It has been suggested that polymorphisms within CYP1A2 impact inter-individual variation in the response to caffeine. The purpose of this study was to explore the acute effects of caffeine on resistance exercise, jumping, and sprinting performance in a sample of resistance-trained men, and to examine the influence of genetic variation of CYP1A2 (rs762551) on the individual variation in responses to caffeine ingestion.
Methods
Twenty-two men were included as participants (AA homozygotes n = 13; C-allele carriers n = 9) and were tested after the ingestion of caffeine (3 mg/kg of body mass) and a placebo. Exercise performance was assessed with the following outcomes: (a) movement velocity and power output in the bench press exercise with loads of 25, 50, 75, and 90% of one-repetition maximum (1RM); (b) quality and quantity of performed repetitions in the bench press exercise performed to muscular failure with 85% 1RM; (c) vertical jump height in a countermovement jump test; and (d) power output in a Wingate test.
Results
Compared to placebo, caffeine ingestion enhanced: (a) movement velocity and power output across all loads (effect size [ES]: 0.20-0.61; p < 0.05 for all); (b) the quality and quantity of performed repetitions with 85% of 1RM (ES: 0.27-0.85; p < 0.001 for all); (c) vertical jump height (ES: 0.15; p = 0.017); and (d) power output in the Wingate test (ES: 0.33-0.44; p < 0.05 for all). We did not find a significant genotype × caffeine interaction effect (p-values ranged from 0.094 to 0.994) in any of the analyzed performance outcomes.
Conclusions
Resistance-trained men may experience acute improvements in resistance exercise, jumping, and sprinting performance following the ingestion of caffeine. The comparisons of the effects of caffeine on exercise performance between individuals with the AA genotype and AC/CC genotypes found no significant differences.
Trial registration
Australian New Zealand Clinical Trials Registry. ID: ACTRN12619000885190.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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