Photobiomodulation for Parkinson's Disease in Animal Models: A Systematic Review
Salehpour F, Hamblin MR
Biomolecules · 53 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Institute of Allergy and Infectious Diseases
- Government
- NIAID NIH HHS
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Institute of Allergy and Infectious Diseases (R01 AI050875); National Institute of Allergy and Infectious Diseases (R01AI050875R21AI121700); National Institute of Allergy and Infectious Diseases (R21 AI121700)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-04-15 · Biomolecules · vol. 10 · issue 4 · p. 610
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 72 citations · more than 90% of similar papers · 2.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 62 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Laser Applications in Dentistry and Medicine
- Keywords
- Deep brain stimulation, Substantia nigra, Dopamine, Parkinson's disease, Neuroscience, Adverse effect, Medicine, Animal studies, Disease, Clinical trial, Internal medicine, Psychology
- MeSH
- animals, humans, parkinson disease, disease models, animal, publications, low-level light therapy
2 authors
From US, ZA
- Farzad SalehpournLIGHT (United States)
- Michael R. Hamblin · correspondingHarvard University; University of Johannesburg; Massachusetts General Hospital
Abstract
Photobiomodulation (PBM) might be an effective treatment for Parkinson's disease (PD) in human patients. PBM of the brain uses red or near infrared light delivered from a laser or an LED at relatively low power densities, onto the head (or other body parts) to stimulate the brain and prevent degeneration of neurons. PD is a progressive neurodegenerative disease involving the loss of dopamine-producing neurons in the substantia nigra deep within the brain. PD is a movement disorder that also shows various other symptoms affecting the brain and other organs. Treatment involves dopamine replacement therapy or electrical deep brain stimulation. The present systematic review covers reports describing the use of PBM to treat laboratory animal models of PD, in an attempt to draw conclusions about the best choice of parameters and irradiation techniques. There have already been clinical trials of PBM reported in patients, and more are expected in the coming years. PBM is particularly attractive as it is a non-pharmacological treatment, without any major adverse effects (and very few minor ones).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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