Music Intervention Reduces Persistent Fibromyalgia Pain and Alters Functional Connectivity Between the Insula and Default Mode Network
Usui C, Kirino E, Tanaka S, Inami R, Nishioka K, Hatta K, Nakajima T, Nishioka K, Inoue R
Pain medicine (Malden, Mass.) · 20 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Japan Society for the Promotion of Science
- University or hospital
- Research Support Foundation 2018 of the Juntendo Institute of Mental Health
- Grants
- Japan Society for the Promotion of Science (19K08026); Japan Society for the Promotion of Science (15K00380)
Based on 2 listed funder(s).
Publication
- Published
- 2020-02-18 · Pain Med · vol. 21 · issue 8 · pp. 1546–1552
- Publisher
- Oxford University Press
- Cited
- 37 citations · more than 90% of similar papers · 2.4× the field average
- References
- 33 works
- Access
- Paywalled
- Research areas
- Fibromyalgia and Chronic Fatigue Syndrome Research · Musculoskeletal pain and rehabilitation · Pain Mechanisms and Treatments
- Keywords
- Default mode network, Insula, Functional magnetic resonance imaging, Fibromyalgia, Medicine, Physical therapy, Precuneus, Music therapy, Functional connectivity, Audiology, Physical medicine and rehabilitation, Psychology, Neuroscience
- MeSH
- brain, cerebral cortex, neural pathways, humans, fibromyalgia, magnetic resonance imaging, music therapy, brain mapping, pilot projects, music, female, default mode network
9 authors
From JP
- Chie Usui · correspondingJuntendo University; Juntendo University Nerima Hospital
- Eiji KirinoJuntendo University; Juntendo University Shizuoka Hospital
- Shoji TanakaSophia University
- Rie InamiJuntendo University
- Kenya NishiokaNational Graduate Institute for Policy Studies; Juntendo University
- Kotaro HattaJuntendo University; Juntendo University Nerima Hospital
Abstract
Objective
The aims of the present study were to examine the effects of short-term music interventions among patients with fibromyalgia (FM) and to clarify the alterations in functional connectivity and persistent pain.
Design
Pilot study.
Setting
All participants were evaluated at Juntendo University from November 2017 to January 2019.
Subjects
We enrolled female patients who had been clinically diagnosed with FM (N = 23).
Methods
All participants listened to Mozart's Duo for Violin and Viola No. 1, K. 423, in a quiet room for 17 minutes. We compared the degree of pain using resting-state functional magnetic resonance imaging and the numeric rating scale before and after listening to music.
Results
Pain scores were significantly reduced after listening to music. Further, we observed there was a significant difference in connectivity between the right insular cortex (IC) and posterior cingulate cortex (PCC)/precuneus (PCu) before and after listening to music. We also found that the difference between the right IC-PCu connectivity and the difference in pain scores were significantly correlated.
Conclusions
We found that a short period of music intervention reduced chronic pain and altered functional IC-default mode network connectivity. Furthermore, music potentially normalized the neural network via IC-default mode network connectivity, yielding temporary pain relief in patients with FM. Further longitudinal studies with larger sample sizes are required to confirm these results.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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