Funded in part by U.S. Highbush Blueberry Council, US Highbush Blueberry Council
Effect of Blueberry Consumption on Cardiometabolic Health Parameters in Men with Type 2 Diabetes: An 8-Week, Double-Blind, Randomized, Placebo-Controlled Trial
Stote KS, Wilson MM, Hallenbeck D, Thomas K, Rourke JM, Sweeney MI, Gottschall-Pass KT, Gosmanov AR
Current developments in nutrition · 55 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Industry group
- U.S. Highbush Blueberry Council
- Industry group
- US Highbush Blueberry Council
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2020-03-06 · Curr Dev Nutr · vol. 4 · issue 4 · p. nzaa030
- Publisher
- Elsevier BV
- Cited
- 78 citations · more than 96% of similar papers · 3.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Phytochemicals and Antioxidant Activities · Phytoestrogen effects and research · Food composition and properties
- Keywords
- Type 2 diabetes, Fructosamine, Placebo, Medicine, Evening, Diabetes mellitus, Aspartate transaminase, Alanine transaminase, Internal medicine, Morning, Randomized controlled trial, Gastroenterology, Animal science, Endocrinology, Chemistry, Biology, Biochemistry, Alkaline phosphatase
8 authors
From US, CA
- Kim S. Stote · correspondingAlbany Stratton VA Medical Center Albany
- Margaret Mary WilsonAlbany Stratton VA Medical Center Albany
- Deborah HallenbeckAlbany Stratton VA Medical Center Albany
- Krista ThomasSage Colleges
- Joanne M RourkeAlbany Stratton VA Medical Center Albany
- Marva I. SweeneyUniversity of Prince Edward Island
Abstract
Background
Blueberries are dietary sources of polyphenols, specifically anthocyanins. Anthocyanins have been identified as having a strong association with type 2 diabetes risk reduction; however, to date few human clinical trials have evaluated the potential beneficial health effects of blueberries in populations with type 2 diabetes.
Objectives
We investigated the effects of blueberry consumption for 8 wk on cardiometabolic parameters in men with type 2 diabetes.
Methods
In a double-blind, parallel-arm, randomized controlled trial, 52 men who are US veterans [mean baseline characteristics: age, 67 y (range: 51-75 y); weight, 102 kg (range: 80-130 kg); BMI (in kg/m2), 34 (range: 26-45)] were randomly assigned to 1 of 2 intervention groups. The interventions were either 22 g freeze-dried blueberries or 22 g placebo. The study participants were asked to consume 11 g freeze-dried blueberries or placebo with each of their morning and evening meals along with their typical diet.
Results
Mean ± SE hemoglobin A1c (7.1% ± 0.1% compared with 7.5% ± 0.2%; P = 0.03), fructosamine (275.5 ± 4.1 compared with 292.4 ± 7.9 µmol/L; P = 0.04), triglycerides (179.6 ± 10.1 compared with 199.6 ± 19.9 mg/dL; P = 0.03), aspartate transaminase (23.2 ± 1.4 compared with 30.5 ± 2.7 units/L; P = 0.02), and alanine transaminase (35.6 ± 1.5 compared with 48.3 ± 2.9 units/L; P = 0.0003) were significantly lower for those consuming blueberries for 8 wk than for those consuming the placebo. Fasting plasma glucose concentrations; serum insulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, and C-reactive protein concentrations; blood pressure; and body weight were not significantly different after 8 wk consumption of blueberries compared with the placebo.
Conclusions
Consumption of 22 g freeze-dried blueberries for 8 wk may beneficially affect cardiometabolic health parameters in men with type 2 diabetes.This trial was registered at clinicaltrials.gov as NCT02972996.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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